Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

A method is presented that makes possible the labelling of powders that can be applied as building material in a layer-additive manufacturing method such as a selective laser sintering method. To this effect the powder is mixed with at least one salt of a metal of the rare earths, wherein the salt has the property that it shows a luminescence when being irradiated with photons having a wavelength outside of the visible spectrum or with particle radiation. Thereby, parts that have been manufactured by means of the layer-additive manufacturing method can be identified with regard to the manufacturer, the place of manufacture or the manufacture date.

Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

A method for manufacturing a wavelength converting film is provided. A release film is provided. At a least one coating process is performed to form at least one wavelength converting layer on the release film, wherein a first contact surface of the at least one wavelength converting layer and the release film has a first roughness. An adhesive layer is formed on a surface of the wavelength converting layer farthest from the release film, wherein a second contact surface of the adhesive layer and the wavelength converting layer has a second roughness. The second roughness is greater than the first roughness.

Impact-dissipating liners, helmets having an impact-dissipating liner, and methods of fabricating impact-dissipating liners are provided. The liners include a fluid impermeable enclosure having cavities with sidewalls and a fluid contained in the enclosure. The enclosure may have a central portion and lobes extending from the central portion, wherein the central portion and the lobes are adapted to conform to the shape of an internal surface of a helmet. The helmets may include bodies positioned within the cavities of the liner, where, under impact loading, contact between the bodies and the liner absorbs at least some of the energy of the impact loading. Aspects of the invention are particularly adapted for use for head protection, such as, helmets; however, aspects of the invention are also adaptable to provide impact-dissipation for any body or surface that would benefit from such protection.

Disclosed herein are simulated fibrous tissue models of anatomical parts for surgical training. The non-dissolvable simulated fibrous tissue model is made of a polyvinyl alcohol (PVA) and fibrous material composite to simulate realistic tissue properties and behaviors. The simulated fibrous tissue model may be a standalone model of an anatomical part or may be used in a complementary anatomical simulation kit to provide a more comprehensive training approach.

A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate.

Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.

A process for manufacturing a rubber patch comprising a radiofrequency transponder, the patch having a first layer and a second layer, the method comprising moulding and vulcanizing a first layer, the exterior surface of which comprises a cavity able to receive a radiofrequency transponder, placing a transponder in the cavity, and then placing and vulcanizing a second layer in order to embed the transponder between the two layers.