A hand tool with a replaceable workpiece head includes a handle and a workpiece head. A rear end of the workpiece head is provided with an insertion block. A front end surface of the handle is provided with an insertion hole. The insertion block of the workpiece head is inserted into the insertion hole. A side wall of the handle is provided with a receiving slot which is communicated with the insertion hole. A rear end of the insertion block is provided with a locking part. The receiving slot is provided with a movable locking member and a pushing mechanism. The pushing mechanism is capable of pushing the movable locking member such that the movable locking member and the locking part are engaged with each other.