A machine suitable for marking codes on rodent tails is disclosed, for marking both machine-readable and human-readable codes and such codes combined. An embodiment comprises two axes of motion: one aligned with the rodent tail and one perpendicular. Only one axis need move at one time for disclosed codes. One axis is linear motion of a marking head on a gantry. The second axis provides a rolling motion of the rodent tail. Codes include symbol sets consisting of orthogonal straight line segments, including both a reduced alphanumeric symbols set and a vine code with a marked spine. Delete markings and replacement locations are defined for marking error correction. Embodiments include mapping tables from animal codes as marked to animal IDs for use in managing animals in vivaria. The mapping tables also provide error detection.

A marking/drying tool applies ink to biological tissue using a single handheld device. A cylindrical body retains a felt tip movable between a retracted position within the body and an extended position outside the body for marking the tissue. A gas source has a manual valve to selectably dispensing a drying gas onto the tissue. In a preferred embodiment, an interlock prevents dispensing of drying gas when the tip is in the extended position and prevents the tip moving to the extended position when the manual valve is dispensing the drying gas.

Systems and methods of measuring drug efficacy and side effects using non-invasive or husbandry-only testing are described. Steps include testing a cohort with a proposed husbandry-only protocol against an existing gold-standard treatment, and then validating the use of a created surrogate, non-invasive metric in place of an invasive metric. Then, the validated non-invasive surrogate metric and the husbandry-only protocols are used with an animal treatment cohort to study a new proposed treatment. A control cohort is also used, subject to the same husbandry-only testing and the surrogate metric. A statistical difference in outcomes, using one or more surrogate metrics, between the treatment cohort and the control cohort is the drug efficacy, for a drug used to treat the treatment cohort.

Embodiments of the invention include an apparatus, a computer-implemented method, and a computer program product for branding a quick response code onto a surface. Aspects of the invention include a branding device having a plurality of thermoelectric devices on a substrate. Each of the thermoelectric devices is arranged on the substrate as a single bit in a quick response pattern. Each of the thermoelectric devices includes an n-type thermoelectric element electrically coupled to a p-type thermoelectric element. The thermoelectric elements can be individually heated or cooled using the Peltier effect.

A marker capsule for a drug delivery dart that marks a animal upon impact to indicate it has had a drug injection. The marker capsule is formed of a rupturable material, and has a central aperture formed therethrough for disposition about a cannula extending from the drug delivery dart. A marking substance is contained within the capsule. The capsule ruptures between the dart body and the animal upon impact to thereby disperse said marking substance upon the animal about the area of the impact.

A system for attaching a radio frequency identification (RFID) tag to an animal when received thereby. The system is configured for mounting thereto a RFID tag magazine comprising a plurality of cannulas that each contain at least one RFID tag (15), wherein the RFID tag magazine is configured for presentation of any one of the plurality of cannulas to the animal when so received.

The invention is directed to an animal marking and treatment apparatus. The marking apparatus is an animal treatment apparatus to apply an animal treatment to a surface or subcutaneous layer of an animal via an operative end. The marking apparatus includes a marking portion, attached to the animal treatment apparatus, and located at the operative end. The marking apparatus is located such that when the animal receives the treatment the marking portion marks the animal by stamping at the same time.

Microneedle patches have been developed that can be used to deliver therapeutic, prophylactic, diagnostic agents and/or dyes to the skin. The microneedles encapsulate the agent(s) to be delivered. These are formed of a biodegradable polymer that dissolves upon insertion into skin or tissue, so that the microneedles break off from the substrate forming the patch, remaining in the skin/tissue at the site of insertion. The patches are used to create a tattoo or to deliver therapeutic, prophylactic or diagnostic agent in combination with a tattoo. In one embodiment, the microneedle patch contains both vaccine and dye pigments to administer vaccine and record such administration in one application of the microneedle patch.

A livestock management system is provided that spray marks animals for sorting or market weight selection. The system includes a pen area partitioned into a feeding area containing at least one feeder and a common watering area containing at least one waterer. A walk-through scale has an inlet open to the watering area and an outlet open to the feeding area. The walk-through scale has a weighing device that determines if the animal is within the specified set weight for marking. The weighing device determines the weight of the animal as the animal center of mass crosses the center of the weighing platform. The system allows spray marking of the animal to be done in a stress free environment that improves overall growth potential.

A branding bracket is provided that has a bracket assembly and branding irons. The bracket assembly has a guide plate having two or more notches cut out of a top surface that receive the shaft of a branding iron. Guides are attached to the rear surface of the guide plate. When a branding iron is placed in the notch, a sleeve positioned on the shaft of the branding iron is slid over the guide to lock the branding iron to the bracket assembly, while still allowing the branding irons to move independently of one another. In one arrangement, the guide plate has multiple notches to allow the use of different sized branding irons, such as 3, 4 and 5 irons.