In some embodiments, a sealing and pressure dosing apparatus may be provided. The sealing and pressure dosing apparatus may include a sealing machine having one or more of a driven turret, a sealing head, a pressure sealing member, and a pressure sealing chamber. The sealing and pressure dosing apparatus may also include a pressure dosing system which may be integrated with the sealing machine.

A control method of an electromechanical apparatus (10) for installing a plunger tip (31) in a syringe (21), the control method comprising: providing a syringe (21) with at least one opening (22); providing a plunger tip (31) configured for snug insertion in the opening (22); pushing the plunger tip (31) inside the syringe (21), by a pusher rod (60) of the electromechanical apparatus (10), the plunger tip (31) passing through an intermediate cannula element (50); monitoring over time a force exchanged between the plunger tip (31) and the pusher rod (60), providing a force signal (401, 402, 403, 404) by a force detector (61) of the electromechanical apparatus (10); analyzing the force signal (401, 402, 403, 404) to determine an installation status of the plunger tip (31) in the syringe (21).

An apparatus and a method for closing containers with closures is disclosed. The apparatus includes a transport wheel, a feed device, and a closing device. The transport wheel continuously transports the containers and includes a plurality of transport wheel receptacles. Each transport wheel receptacle is able to receive a container. The transport wheel is designed to be rotatable about a transport wheel axis. The feed device is capable of clocked feeding of the containers to the transport wheel in a feed region of the apparatus. The closing device is arranged to close containers while they are accommodated in the transport wheel receptacles of the transport wheel. A method for closing the containers includes feeding containers to the transport wheel and closing the containers with a closing device.

A cartridge fluid filling system and method for the cannabis and hemp industry. The system comprises a gas-pressurized sanitary reservoir sub-assembly holding material to be dispensed. A spool valve sub-assembly lies in fluid communication with the reservoir sub-assembly and has a spool valve that moves to permit or block fluid flow to a metering rod. Effluent material may pass through an outlet port to a tray sub-assembly for locating cartridges into which metered amounts of the effluent material may be delivered. A robot moves a tray and the outlet port so that material is delivered in precisely metered amounts to cartridges in the tray without waste and in the absence of air bubbles. A human-machine interface includes controllers that supervise related process parameters.

Systems and methods permit gloveless filling containers with a product. A filling arm is disposed within the chamber. An optical sensor is configured to locate and target openings of the containers within the chamber. Locations of the openings are used to guide the filling arm to fill the containers with a product.

Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10.sup.−6 cm.sup.3/s at −80° C. or less.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

The invention relates to a device (IO) for manually inserting a plunger-type stopper into a syringe cylinder, comprising a receptacle (18) designed to hold the syringe cylinder; a tubular barrel (30) designed to accommodate the plunger-type stopper in its interior, a holding device (28) designed to hold the barrel, and a moving device (40, 42, 44, 46, 48) designed to move the plunger-type stopper; the holding device (28) having an actuation portion (34) for moving the barrel (30) relative to the plunger-type stopper. The present invention further relates to a corresponding method.

Methods of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a vacuum chamber, (2) creating a seal between the vacuum chamber and a syringe barrel or a cartridge tube, (3) maneuvering the stopper into a proximal end of the syringe barrel or cartridge tube by a first differential pressure and/or an insertion rod, (4) maneuvering the stopper through the barrel by second differential pressure and/or an insertion rod, (5) optionally sealing a pressure sealing cap to the proximal end of the vacuum chamber, (6) removing the vacuum chamber, insertion rod, and, if present, the pressure sealing cap. The methods are lubricant free or substantially lubricant free. The vacuum chamber may be electropolished and/or extrude honed.

A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.