A unique cap for an automatic test tube recapper is presented. The cap has a conical body with an upper top flange and lower sections for inserting into standard test tubes. The middle section directly under the upper top flange is about 13 mm in diameter. A bottom section under the middle section has a diameter of about 16 mm. The cap has a rounded bottom. The middle and lower sections have diameters similar to the diameters of most common test tubes. One or more nipples with notches cutout are located inside the conical body. The notches grip the lower part of a hammer drive during the driving process but release the hammer drive once the cap has been seated inside the test tube.

Disclosed is a packaging for a number of pre-filled drug cartridges comprising a body to which an infusion set with tubing and needle can be fitted, the body having an open rear end, wherein a stopper is slidably disposed within the body, wherein a peg is arranged on the packaging, the peg having a height which is such that when a cartridge is being put on the peg with the rear end and pushed against it until the rear end abuts a surface of the packaging, the stopper is moved within the body by such a distance that a predetermined volume of a medicament is displaced from the cartridge for priming the cartridge and infusion set.

A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container. A shuttle has an exterior surface and an interior surface. The interior surface is configured for releasably securing the stopper. The shuttle is configured to release the stopper into the fill opening upon application of a releasing force to the exterior surface of the shuttle. A shuttle tray has a shuttle cell. The shuttle cell forms a body with a proximal opening, an interior space, a bottom inner surface opposite the proximal opening, and a side inner surface. The shuttle cell releasably secures the shuttle.

A method for providing a dried solid product containing an active pharmaceutical ingredient is disclosed and includes providing a primary packaging container, providing a drying cartridge different from the primary packaging container, the drying cartridge made of a material adapted to hold a liquid product to be dried, wherein the liquid product contains an active pharmaceutical ingredient and the drying cartridge is made of a material having a thermal conductivity higher than the thermal conductivity of glass. The method also includes filling the liquid product into the drying cartridge, drying the liquid product in the drying cartridge to form a dried solid product containing the active pharmaceutical ingredient, transferring the dried solid product into the primary packaging container.

The invention relates to a device for vacuum stoppering a medical container. The device includes a main body defining an internal volume that has a variable pressure chamber configured to be connected to a vacuum pump. A stopper holder system is arranged in communication with the variable pressure chamber and is configured to receive and hold a stopper aligned with the direction of travel of a piston rod. A piston rod is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container. A container holder system provided in the main body, is arranged distally relative to the stopper holder system and in communication with the variable pressure chamber.

A filling device for aseptic filling of pouches comprising a pouch fill assembly having a movement assembly, a plug removing assembly and a filling assembly. The movement assembly defining an aseptic zone and configured to direct a pouch having a spout and a plug sealing the spout through the pouch fill assembly from an inlet to an outlet. The plug removing assembly having at least one plug removing station including a grasping assembly, a plug retaining structure and an actuator assembly. The filling assembly having at least one filling station structurally configured to dispense a flowable material into the pouch through the spout.

A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23). The dissolving solution can be easily filled in a bubble-free state in the two-chamber type combined container-syringe.

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

A manual check valve for use when priming a fluid supply for a spray gun includes an orifice that opens from the fluid supply into a storage chamber, the storage chamber captures any fluid that is expelled from the fluid supply during priming, and the storage chamber is sealed with a closure. Sealing the storage chamber traps any expelled fluid in the storage chamber and prevents any of the expelled fluid from leaking onto another surface, which keeps the priming operation clean.

Systems and methods are disclosed, which permit filling containers with a product. A filling arm is disposed within a chamber and an optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling arm to fill the containers with a product.