An apparatus, system and method for capping an array of bat pipes. A cap rack is provided with a frame, runners and a matrix of caps. The matrix of caps are aligned respectively over the top open ends of array of bat pipes filled with smokable material. A press tool, having a matrix of pegs and ribs, is aligned over the matrix of caps. Downward pressure of the press tool is applied into the cap rack thereby pressing the matrix of caps into sealed engagement with respective top open ends of the bat pipes. The downward pressure of the ribs of the press tool into the cap rack separates the frame and runners of the cap rack from the matrix of caps leaving the matrix of caps seated in respective top open ends of the bat pipes leaving the array of bat pipes ready for sale, shipping or the like.

A system for capping a mouth of a container may include: a press-on cap for irreversibly capping the mouth of the container, wherein the press-on cap is made of polymeric material able to withstand high-temperature sterilization and wherein the press-on cap may include: a tubular sleeve extending along an axis of extension and configured to be irreversibly locked to the mouth of the container; a rim that radially projects out of the tubular sleeve at an end of the press-on cap; a capping wall oriented transverse to the tubular sleeve and extending from the rim over a front surface delimited by the rim, wherein the front surface faces outwardly; and a plurality of protrusions, which extend out of the front surface. The front surface may have a height variation relative to the rim across the front surface ranging from −1% to 1% of a characteristic dimension of the capping wall.

A method of preparing a prefilled syringe is disclosed that includes obtaining a syringe barrel and a needle adaptor cap assembled on the tip of the syringe barrel, wherein the needle adaptor cap has a rubber element tightly sealing the orifice of the tip of the syringe barrel and the syringe barrel together with the needle adaptor cap assembled on the tip of the syringe barrel is sterilized by a first sterilizing. Filling a drug substance into an interior of the syringe barrel and sealing the interior of the syringe barrel. Packaging the syringe barrel with a rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel. Providing a second external surface sterilizing of the packaged syringe barrel with the rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel.

A beverage product has a beverage container, a quantity of a beverage in the beverage container, a flexible, compressible plug sealing the beverage container, and a contiguous molded lid having a cylindrical upper portion with a top having a matrix of openings, a cavity in the upper portion below the top, the cavity open to the underside, a shoulder facing downward, and a descending skirt below the shoulder, the descending skirt separated by a plurality of vertical slots into a plurality of flexible tabs having each a lowermost, inwardly facing lip, the contiguous molded lid engaged to the beverage container by the flexible tabs.

The present invention involves both an apparatus and an associated method for confirming the presence or absence of closures in a closure nest inside an aseptic chamber. The apparatus comprises a topographical profiler disposed to monitor the closure nests. Vertical displacements in topographical maps obtained by the profiler are compared with information from a database about the nest and closure combinations. Vertical displacements falling outside predetermined upper and lower bounds are deemed absences of closures. The topographical profiler may be disposed outside the aseptic chamber. The system may be automated via a controller and suitable software. In some embodiments the nests and disposed in the monitored area by robotic articulated arms. In other embodiments the closure nests are moved by vacuum pickup systems. The system and method may also be employed to assess the suitability of a closure nest for closing in an aseptic chamber containers in a container nest.

Systems and methods permit gloveless filling containers with a product. A filling arm is disposed within the chamber. An optical sensor is configured to locate and target openings of the containers within the chamber. Locations of the openings are used to guide the filling arm to fill the containers with a product.

The system of the invention involves a gloveless aseptic processing system. The automated system is for filling nested pharmaceutical containers with a pharmaceutical fluid substance. A closed sterilizable gloveless isolator chamber is capable of maintaining an aseptic condition, having a sterilization system. The container filling system has a dispensing head for filling the containers, and a container closing system disposed within the gloveless isolator chamber with rams for pushing closures into openings of the nested containers. The container manipulation mechanism is disposed within the gloveless isolator chamber and is capable of positioning the nested pharmaceutical containers within the gloveless isolator chamber including operably disposing the nested pharmaceutical containers with the container filling system and the container closing system. Container tubs sealed by removable covers and contain a container nest bearing a plurality of pre-sterilized pharmaceutical containers.

In one example in accordance with the present disclosure, a spout for a print liquid reservoir is described. The spout includes a sleeve having an opening through which print liquid passes. A first flange extends outward from the sleeve to affix the spout to the print liquid reservoir. A second flange extends outward from the sleeve to sit on a wall a container in which the print liquid reservoir is disposed. The spout also includes an angled clamp flange having an angled surface and a straight surface opposite the angled surface. The angled clamp flange is to affix the spout to the container.

A modular production system including a plurality of production modules connected in a linear series to form a production tunnel, and collectively defining a production channel, and wherein at least one fluid inlet port defined along the production tunnel, said inlet port is in fluid communication with a pressurized fluid source, whereby influx of fluid from said fluid source through said fluid inlet port acts to maintain the fluid pressure within the production channel at a higher pressure than the atmospheric pressure outside of the production tunnel; and wherein one of said production modules positioned between said proximal-most and distal-most production modules comprises a depyrogenator and/or sterilization module, comprising a transparent tubular body, and an irradiation source positioned external to said transparent tubular body, said irradiation source capable of heating the internal environment of the depyrogenation and/or sterilization module to a temperature sufficient to depyrogenate or sterilize articles passing therethrough.

The present invention involves both an apparatus and an associated method for confirming the presence or absence of closures in a closure nest inside an aseptic chamber. The apparatus comprises a topographical profiler disposed to monitor the closure nests. Vertical displacements in topographical maps obtained by the profiler are compared with information from a database about the nest and closure combinations. Vertical displacements falling outside predetermined upper and lower bounds are deemed absences of closures. The topographical profiler may be disposed outside the aseptic chamber. The system may be automated via a controller and suitable software. In some embodiments the nests and disposed in the monitored area by robotic articulated arms. In other embodiments the closure nests are moved by vacuum pickup systems. The system and method may also be employed to assess the suitability of a closure nest for closing in an aseptic chamber containers in a container nest.