An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A cap rotation device includes a cap rotator, a liquid transferring device and an optical detecting device. The liquid transferring device is disposed near the cap rotator, and the optical detecting device is disposed between the cap rotator and the liquid transferring device. The optical detecting device is used to detect a position of a sealing cap of a chemical drum to guide the cap rotator aligning with the sealing cap. Therefore, the sealing cap is opened by the cap rotator, and then the chemical liquid is transferred by the liquid transferring device.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck defining an opening that provides fluid communication with the interior; a cap assembly including a funnel having a first portion and a second portion, where the second portion extends radially outward from the first portion to form a floor on an interior thereof and a shoulder on an exterior thereof, the first portion defining a first bore and the second portion defining a second bore fluidly connected to the first bore; a self serum stopper having a self sealing membrane that extends radially outward to overlie at least a portion of the floor of the funnel; and a cap having a cap wall sized to fit over the funnel and a cover portion extending radially inward from the cap wall.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A multifunction cap replacement module includes a cap rotation module supporter and at least one cap rotation module. The cap rotation module is mounted to the cap rotation module supporter, and the cap rotation module includes a first cap rotation device and a second cap rotation device. The first cap rotation device is configured to open one sealing cap of at least one chemical drum and extract a chemical liquid from the chemical drum, and the second cap rotation device is configured to open another one sealing cap of the chemical drum and allow the chemical liquid to flow back to the chemical drum.

A cap rotation device includes a cap rotator, a liquid transferring device and an optical detecting device. The liquid transferring device is disposed near the cap rotator, and the optical detecting device is disposed between the cap rotator and the liquid transferring device. The optical detecting device is used to detect a position of a sealing cap of a chemical drum to guide the cap rotator aligning with the sealing cap. Therefore, the sealing cap is opened by the cap rotator, and then the chemical liquid is transferred by the liquid transferring device.

A disposable isolator including a bottom, a flexible peripheral wall defining a clean and sterile inner volume, a first pair of joining parts forming a first tight junction at the bottom, this first pair including an inner part placed inside the inner volume and suitable for positioning containers, and an outer part placed outside the inner volume and suitable for cooperating by shape matching with a positioning cavity provided on a support table, and a second pair of joining parts forming a second tight junction at the peripheral wall and including an outer part suitable for being connected to a robot, and an inner part suitable for being connected to a manipulating tool, the first and second pairs being designed so that the robot applies the manipulating tool on the containers positioned on the support table.

An automated drum manipulation system and methods include at least one among an automated drum rotator, bung locator, bung plug extractor and bung plug installer. The bung locator includes at least two spaced-apart bung location sensors and at least one downwardly-extending foot spaced outwardly relative to the sensors and configured to rest upon the drum's outer rim, positioning the sensors over the upper surface of the drum so they can concurrently detect the presence of opposing sides of the lip of the drum's bung opening as the drum is rotated below the bung locator.

The present disclosure provides a dual-seal reverse pressure differential cartridge E-liquid injection method. The method includes: selecting an E-liquid guiding body configured to absorb, to a maximum degree, an E-liquid stored in an E-liquid storage tank, to avoid leakage of the E-liquid, while providing a smooth supply of the E-liquid. The method also includes assembling the E-liquid guiding body with a cartridge that includes an E-liquid storage tank. The E-liquid guiding body is in fluidic communication with the E-liquid in the E-liquid storage tank. In a negative pressure environment, the E-liquid is injected into the E-liquid storage tank. The E-liquid has a pressure P1. After the injection is completed, the cartridge is placed in a sealing bag, which is then sealed. The pressure inside the sealing bag is P2, P2>P1. The disclosed method can effectively avoid leakage of the E-liquid due to pressure changes in the external atmosphere.

A machine and a method are for the automatic preparation of substances for intravenous application. The machine includes a container receiving zone which defines a matrix of individual positions for initial and final containers, and a number of actuators for transferring substances from initial container to final container. Each of the actuators is positioned beneath the zone for receiving initial and final containers, each of the actuators is able to move relatively, independently of the rest of the actuators, and each of the actuators is suitable for receiving and operating injectors with different volumes and degrees of precision in order to remove substances from initial containers and insert them into final containers.