The method for packaging articles provides to form a tubular wrapping of thermosealable sheet material inside which the articles to be packaged are prearranged, regularly distanced, and to feed said tubular wrapping to a cut station at which grip means, suitable to grasp in succession said articles, operate. The transverse cut of the tubular wrapping is performed in suitable step relationship in the section upstream the article grasped by said grip means and the prepackaged article is transferred to a closure rotatable head for closing the package, rotatable at a plurality of operative stations. In a first operative station the bellows folding of the open ends of the portion of tubular wrapping containing the article is performed. Successively, the sealing of said bellows folded ends of the wrapping is performed to obtain the airtight closure of the package.

An ultrasonic system and method for sealing a complex interface, such as a Gable top, having multiple and a variety of layers across the interface, or an oval or round spout having a complex geometry. The system includes two ultrasonic horns arranged opposite a gap between which the interface is provided. The frequency and phase of the ultrasonic energy are synchronized as the energy is applied simultaneously while the interface is pressed between a jaw and the energy is applied to both sides of the interface. Only one application of the frequency- and phase-synchronized ultrasonic energy is required to hermetically seal all the layers of the interface together.

A container for packaging a pre-portioned amount of liquid or dry product is provided that includes a one-piece outer casing defining an interior reservoir. The outer casing has a cylindrical shell that is closed at one end by a rounded tip and open at the opposing end with an open circular outer edge/rim defining a mouth. To fill the container, the product is introduced through the mouth into the interior reservoir; then opposing edges of the rim are compressed together and sealed with heat to create an elongated seal having two opposing ends. Multiple types of elongated seals are provided. In one aspect the outer casing is formed unitarily of a plastic resin. To open the container, the consumer squeezes the two opposing seal ends/termini toward each other; this deforms the elongated seal and causes the seal to snap open, which allows access to the product.

A method for manufacture and filling with a sterile liquid of a tubular packaging includes: providing a container with liquid therein, providing a tube, filling the tube with the liquid from the container, dividing the tube into tubular segments by successive welding operations, and separating the tubular segments at the welded seams. After each welding operation the tube is displaced over a distance corresponding to a desired length of the tubular segments, or multiple thereof. During each welding operation pressure can be exerted locally on and energy can be supplied to the tube. Exertion of pressure and the supply of energy can be staggered in time. During each welding operation a temperature at the welded seam can be kept constant. During each welding operation a welding parameter can be measured, and the welding operation can be controlled on the basis of the measured value of the welding parameter.

An assembly fixture device for attaching a vial adapter to a vial includes a base, a support member secured to the base, a handle connected to the support member, a vial adapter grip assembly connected to the handle and comprising an adapter grip member configured to engage and hold a vial adapter, and a vial grip assembly connected to the base comprising first and second grip members that are movable relative to each other and configured to engage and hold a vial. The first grip member is biased toward the second grip member to provide a vial engagement force, where the vial engagement force is about constant when a distance between the first and second grip members is less than 40 mm.

A cartridge assembly for a filling machine includes a plurality of containers. Each container includes a volume and a stem connected to the volume. A connection line grid is in fluid communication with each stem of the plurality of containers. The connection line grid includes a first row connected to one or more containers of the plurality of containers and a second row connected to one or more containers of the plurality of containers. A filter assembly is coupled to the connection line grid.

A method for producing sterile solution-filled containers includes positioning a cartridge onto a filling machine. The cartridge includes a plurality of containers, a filter assembly, and a connection line in fluid communication with the filter assembly. Each of the plurality of containers includes a volume and a stem in fluid communication with the volume and in fluid communication with the connection line. The method includes coupling the cartridge to a feed line in fluid communication with a mix tank, activating a pump coupled to the feed line, and at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, and the connection line to create one or more at least partially filled containers. Further, the method includes sealing and separating each of the filled and sealed containers from the connection line.

An assembly fixture device for attaching a vial adapter to a vial includes a base, a support member secured to the base, a handle connected to the support member, a vial adapter grip assembly connected to the handle and comprising an adapter grip member configured to engage and hold a vial adapter, and a vial grip assembly connected to the base comprising first and second grip members that are movable relative to each other and configured to engage and hold a vial. The first grip member is biased toward the second grip member to provide a vial engagement force, where the vial engagement force is about constant when a distance between the first and second grip members is less than 40 mm.

An assembly fixture device for attaching a vial adapter to a vial includes a base, a support member secured to the base, a handle connected to the support member, a vial adapter grip assembly connected to the handle and comprising an adapter grip member configured to engage and hold a vial adapter, and a vial grip assembly connected to the base comprising first and second grip members that are movable relative to each other and configured to engage and hold a vial. The first grip member is biased toward the second grip member to provide a vial engagement force, where the vial engagement force is about constant when a distance between the first and second grip members is less than 40 mm.

A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.