The present invention relates to a support member for supporting a sealing of a container, to a support system for supporting a sealing of a container, to respective containers and to a method for sealing a container. The support member 100 comprises an injection moulded support structure 110, including a first connecting means 112a; 112b adapted for connecting the support member 100 to a corresponding container 200, a first sealing face 114, and an opening 116 for accessing the sealed container 200 when the support member 100 is connected to the container 200. The support member 100 further comprises a first elastic member 120, wherein the first elastic member 120 at least partially covers the first sealing face 114, and wherein the first sealing face 114 is oriented so that the first elastic member 120 is sandwiched and deformed between the first sealing face 114 and the container 200, when the support member 100 is connected to the container 200.

A receptacle, particularly a closed plastic ampoule produced in a blow molding method and filled in the mold, has a sleeve-type neck part (1) connected to a receptacle body (3) as an axial extension. The neck part forms a seat (11) for a pre-shaped insert (5) and is integrally molded in the mold onto a circumferential surface (9) of the insert (5). The circumferential surface (9) is equipped with at least one surface irregularity (21) having an enclosed base surface such that, due to the integral molding of the neck part (1) onto the circumferential surface (9) of the insert (5), a positive fit is present between the insert and the neck part (1). The fit forms a fixing element. The axial extension of the base surface of the surface irregularity (21) is only a small fraction of the axial extension of the circumferential surface (9).

The invention relates to a method for producing tubular bags made from plastic film or from composite film having a plastic layer on the bag content side, having a self-cutting plastic closure attached to the tubular bag, consisting of a spout part having a fastening flange, a cutting body, which is movably guided in the spout part, and a screw cover having means for activating the cutting body. The film material (5) is supplied from a supply roll to a bag manufacturing machine and the plastic closure is sealed onto the film material in a spout region of a tubular bag. According to the invention, the film material (5) is thinned on the inside of the bag in a ring-shaped region, which is intended for cutting by the cutting body, by means of a thermal embossing process. The plastic closure is then positioned and sealed onto the film material such that the cutting organ embedded in the spout part can become effective in the thinned, ring-shaped region upon use thereof.

The invention relates to a method for producing tubular bags made from plastic film or from composite film having a plastic layer on the bag content side, having a self-cutting plastic closure attached to the tubular bag, consisting of a spout part having a fastening flange, a cutting body, which is movably guided in the spout part, and a screw cover having means for activating the cutting body. The film material (5) is supplied from a supply roll to a bag manufacturing machine and the plastic closure is sealed onto the film material in a spout region of a tubular bag. According to the invention, the film material (5) is thinned on the inside of the bag in a ring-shaped region, which is intended for cutting by the cutting body, by means of a thermal embossing process. The plastic closure is then positioned and sealed onto the film material such that the cutting organ embedded in the spout part can become effective in the thinned, ring-shaped region upon use thereof.

The metering device includes a metering container which can be fitted with screwing action on a standard bottle neck. The metering container has a funnel-shaped base, which is adjoined by a cylindrical lateral wall having, at the upper end, a cross-sectionally u-shaped collar, to which a cover surface can be applied in a form-fitting manner. At the top of the metering device is a pressure-exerting head with an encircling, detachable periphery. A puncturing mechanism having a two-part pressure-exerting pin can be actuated by the pressure-exerting head. The puncturing mechanism is fixed to the cover surface, prior to initial use, and is separated out of the cover surface by a cylindrical casing wall on the pressure-exerting head. The second part of the puncturing mechanism has a punching sleeve, which severs membranes which close the metering container, whereupon the contents of the metering container can be supplied into the bottle.

The invention relates to an assembly for closing a tube, said assembly comprising a tube head that has a neck (10) and a cap (30), said assembly defining a guide path, a thread and a thread portion (11) allowing the cap (30) to be positioned on the neck (10) by cooperation with the guide path and the thread, said assembly comprising a first (24) and a second (25) stop element for said thread portion (11), said stop elements (24, 25) being angularly spaced apart and defining a passage (26) between the guide path and the thread, said assembly being configured to allow axial displacement of the thread portion (11) through the passage (26) with a non-return effect produced by at least one (24) of said stops.

The invention relates to an assembly for closing a tube, said assembly comprising a tube head (3) that has a neck (10) and a closing cover (5) for closing said neck (10), the assembly further comprising a cap (30) which is provided with a piercing element (7) designed to perforate said closing cover (5), the neck (10) and cap (30) being configured such that the cap (30) is guided on the neck (10) into a closed position in which said piercing element (7) has perforated the closing cover, passing via an intermediate position in which the piercing element (7) has finished piercing said closing cover (5), and this also produces a material deformation which seals the closure, said assembly being configured such that the intermediate position is passed through prior to the material deformation which seals the closure.

An assembly for closing a tube, said assembly comprising a tube head (3) provided with a neck (10) and a cap (5) closing said neck (10), said assembly further comprising a stopper (30) comprising a punch (7) adapted to perforate said cap (5), said neck (10) and said stopper (30) being configured to guide the stopper (30) to a closing position in which said punch (7) has perforated said cap (5), characterized in that said cap comprising a lateral skirt (23) provided with at least one notch (60) opening radially, said neck comprising a protrusion (61) configured to cooperate angularly with said notch (60) to block a withdrawal of the cap (30), once said cap (30) is in said closing position

The invention relates to an assembly for closing a tube, said assembly comprising a tube head (3) that has a neck (10) and a closing cover (5) for closing said neck (10), the assembly further comprising a cap (30) which is provided with a piercing element (7) designed to perforate said closing cover (5), the neck (10) and cap (30) being configured such that the cap (30) is guided into a closed position in which said piercing element (7) has perforated the closing cover (5), said piercing element comprising one or more teeth (50) for cutting through the closing cover (5), which extend from a free edge (80) of the piercing element (7), at least one angular portion (81) of said free edge (80), referred to as the passage portion, being configured to remain in the neck (10) when in said closed position.

Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.