A bone cement applicator comprising a cartridge with an internal space. The cartridge has a head with a dispensing opening for expulsion of bone cement, a dispensing plunger, a receptacle mobile in the cartridge, and a mixing rod with a mixer fastened to it and arranged in the internal space of the cartridge. The mixing rod is detachably connected, on a side opposite from the mixer, to a front side of the receptacle that faces the cartridge head. When the mixing rod is detached from the receptacle and the receptacle is propelled in the direction of the cartridge head the mixing rod can be pushed into the receptacle. A method is also disclosed for production of a bone cement using the bone cement applicator.

A handheld applicator for delivery of post-treatment coating following application of a conversion coating includes a first vessel extending longitudinally and containing Socosurf PACS solution, a second vessel extending longitudinally and containing hydrogen peroxide, a pH indicator contained in one of the first or second vessels, a mixing region configured to combine the Socosurf PACS solution, hydrogen peroxide, and pH indicator.

A vibration mixer suitable for a cartridge having a longitudinal axis and containing a multi-component material, preferably a two-component material, stored in at least two separated chambers inside the cartridge; the vibration mixer including a cartridge holder and a drive for the cartridge holder; the cartridge holder is configured for receiving and locking only one end of the cartridge and is configured for maintaining the longitudinal axis of the cartridge on the cartridge holder in a vertical position.

A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.

A manual mixer serves to facilitate mixing and agitating materials for use during surgery. The manual mixer includes a mixing assembly and an actuation assembly for actuating the mixing assembly. The mixing assembly includes at least a paddle portion and a plunger portion. The plunger portion is simultaneously capable of rotational movement with the paddle portion and movement upwardly or downwardly along the paddle portion. Rotation of the paddle portion serves to facilitate mixing and agitating of the materials, and downward movement of the plunger portion serves to facilitate dispensing of the materials from the manual mixer.

The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.

Varied embodiments of a container/dispenser having a multi-chamber bellows member having a plurality of collapsible bellows chambers allowing more than one substance to be contained within the container and simultaneously dispensed when a sufficient axial force is exerted on a platform to compress the bellows member forcing flowable materials from each chamber. In an alternative embodiment, the present invention discloses a retrofit multi-chambered bellows container, which may be adapted to a standard caulking tube container.

A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.

Systems and methods for embolizing body lumens are provided that include a mixing component provided in a flow path between two chambers, e.g., syringes, such that one or more actuators may direct embolic material back and forth between the two chambers through the mixing component to mix the embolic material. Once mixed, the embolic material may be delivered from one of the chambers through a catheter into a patient's body to embolize a target location.