A device for mixing and dispensing bone material is provided. The device comprises a tubular member having an interior surface configured to receive bone material and a fluid to mix the bone material disposed within the tubular member. The tubular member is flexible and has a proximal opening configured to slidably receive a plunger, and a distal opening configured to dispense a mixed bone material from the interior surface of the tubular member. The plunger is less flexible than the tubular member. Methods of mixing and dispensing bone material are also provided.

Disclosed herein is a system for creating an injectable and flowable cold slurry, the system comprising a housing; a mount operatively connected to the housing configured to accept a container; a first motor configured to move the mount from a first position to a second position; a second motor; and a drive shaft in communication with the second motor, wherein the drive shaft is configured to rotate to cause an internal volume of the container to be transformed into the injectable and flowable cold slurry.

The invention provides containers for pressuring an aqueous liquid with a gas to increase the concentration of the gas in the aqueous liquid. The container employs one or more moveable sections to reduce the accessible volume of the container, e.g., allowing gases such as H2 to become supersaturated within an aqueous liquid.

One aspect relates to a method of producing a bone cement from at least two starting components in a device comprising a first hollow cylinder-shaped container and a second hollow cylinder-shaped container, a vessel arranged in the first container, whereby a monomer liquid is stored in the vessel. The aspect also relates to a device for providing a bone cement from two starting components, comprising a hollow cylinder-shaped first container, in which a vessel for a monomer liquid as first starting component can be stored, a hollow cylinder-shaped second container comprising a first internal space, in which a bone cement powder as second starting component can be stored, and a second internal space into which the monomer liquid can be conveyed, a fluid-conducting conveying means arranged between the first internal space and the second internal space, whereby the first container and the second container are axially connected to each other.

Problem: To supply a device and a method for accurately discharging a fixed amount of a liquid, the liquid containing solid particles, in a state that the solid particles are dispersed in the liquid material. Solution: A discharge device for a liquid material containing solid particles includes a first reservoir, a first air pressure supply pipe, a metering portion having a metering hole, a plunger moving back and forth in the metering hole, a nozzle, a switching valve having a first position and a second position, a plunger driver, and a switching valve driver. The discharge device further includes a second reservoir, a second air pressure supply pipe, a branch portion provided in an upper portion of the metering hole and having a branch flow path, and an opening/closing mechanism that establishes or cuts off communication between the second reservoir and the metering hole. In the discharge device, the liquid material inside the first reservoir can be transferred to the second reservoir, and the liquid material inside the second reservoir can be transferred to the first reservoir. A discharge method is carried out using the discharge device.

One aspect relates to a device for mixing a polymethyl methacrylate bone cement formed of two starting components and for storing the starting components of the bone cement. The device has a tubular cartridge with a cylindrical interior. A powder is contained in a front of the cartridge and a container containing a monomer liquid is arranged in a rear of the cartridge. A discharge piston is arranged between the container and the powder, and a conveying piston is on the side of the container opposite the discharge piston. The discharge piston and the conveying piston are arranged in the interior of the cartridge movably in the longitudinal direction. A conduit is provided that connects the front part and the rear part of the interior of the cartridge to one another in a manner permeable for the monomer liquid and for gases and which is impermeable for the powder.

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.

One aspect relates to a device for producing a bone cement paste from a monomer liquid and a cement powder as parent components of the bone cement paste and for delivering the mixed bone cement paste, the device having a cartridge having a cylindrical interior. The interior of the cartridge is closed on the front side except for a delivery opening for expelling the bone cement paste. A delivery plunger is arranged in the interior of the cartridge. The cement powder is arranged in the interior of the cartridge. A closure is arranged on the front side of the delivery plunger. The closure closes the delivery opening when the delivery plunger is pressed against the front side of the interior of the cartridge. The closure blocks a further movement of the delivery plunger so that the delivery plunger is spaced from the front side of the interior of the cartridge at least in some areas and a dead volume remains in the interior of the cartridge when the delivery plunger is pressed against the front side of the interior of the cartridge.

A facial pack manufacturing apparatus capable of discharging a mixture without a remnant, according to the present invention, comprises a main body formed with an injection hole into which a raw material of a facial pack and a solid agent are injected; a mixing unit for mixing the raw material and the solid agent introduced into the injection hole of the main body, and discharging the mixture; and a pack manufacturing unit for receiving the mixture discharged from the mixing unit and manufacturing the mixture into a facial pack, wherein the mixing unit includes: an upper body including a blade protruding downward so as to be rotatable; a lower body coupled to a lower portion of the upper body so that an upper side thereof is opened to insert the blade, and having a discharge unit through which the mixture is discharged and a through hole passing through the discharge unit; and an opening and closing unit, provided in the through hole so as to be vertically movable, for opening and closing the discharge unit.