A storage and mixing system, for pasty two-component polymethyl methacrylate bone cements, comprises a cartridge with a cylindrical interior, a cartridge head that closes an end of said cartridge, a partition wall axially disposed in the cylindrical interior of the cartridge, wherein said partition wall is connected to the circumferential surface of the cylindrical interior of the cartridge and divides the cylindrical interior of the cartridge delimited by the cartridge head into two spatially separate cavities. The first cavity includes a first pasty cement component and the separate second cavity includes a second pasty cement component, two delivery plungers close the two cavities on the side of the cavities opposite the cartridge head. At least two cutting edges are disposed on the front side of the sleeve-shaped connecting means facing the cartridge head, such that the at least two cutting edges cut off the partition wall from the cylindrical inner wall of the cartridge as at least one cut-off strip when the delivery plungers are advanced towards the cartridge head in the cavities with the connecting means, and wherein the sleeve-shaped connecting means comprises a deflecting surface which is inclined to the axis of the connecting means which, on advancing the connecting means, presses the at least one cut-off strip of the partition wall towards the inner wall of the cartridge.

An apparatus for producing a composition that includes nano-bubbles dispersed in a liquid carrier includes: (a) an elongate housing comprising a first end and a second end, the housing defining a liquid inlet, a liquid outlet, and an interior cavity adapted for receiving the liquid carrier from a liquid source; and (b) a gas-permeable member at least partially disposed within the interior cavity of the housing. The gas-permeable member includes an open end adapted for receiving a pressurized gas from a gas source, a closed end, and a porous sidewall extending between the open and closed ends having a mean pore size no greater than 1.0 μm. The gas-permeable member defines an inner surface, an outer surface, and a lumen. The housing and gas-permeable member are configured to form a composition that includes the liquid carrier and the nano-bubbles dispersed therein.

A vane for an impeller of an agitator for mixing or agitating a process fluid includes a socket for mounting the vane to an impeller and a blade for mixing or agitating the process fluid, the blade being connected to the socket, the blade having a leading edge, a trailing edge, and a blade tip extending from the leading edge to the trailing edge at the end of the blade facing away from the socket, and the blade having a height and a width. The height is the maximum distance of the blade tip from the socket and the width is the distance of the leading edge from the trailing edge. The blade has a maximum width that is at least 55 percent.

A storage and mixing system for pasty two-component polymethyl methacrylate bone cements comprises a tubular cartridge having a cylindrical inner chamber, a dispensing plunger that is axially displaceable in the inner chamber of the cartridge, a partition disposed axially in the tubular cartridge, and a cartridge head which closes one end of the tubular cartridge. The cartridge head has a slot-shaped opening, wherein the partition protrudes from the inner chamber of the cartridge through the slot-shaped opening of the cartridge head, wherein the partition divides the cylindrical inner chamber of the cartridge bounded by the dispensing plunger and the cartridge head into two cavities that are spatially separated from one another. A first pasty cement component is present in the first cavity and a second pasty cement component is present in the separate second cavity, wherein the partition is removable through the slot-shaped opening of the cartridge head so that the two separate cavities are connected to one another after the partition is removed.

A flow distribution system for distributing and dividing the flows of at least two separate fluids, the distribution system comprising: a three-dimensional nested structure of at least two fluid transporting fractals comprising at least a first fluid transporting fractal and a second fluid transporting fractal, each fluid transporting fractal having a respective fluid inlet which bifurcates to a plurality of fluid outlets, each fluid transporting fractal being configured to facilitate a flow therethrough independent from a flow in the other fluid transporting fractal, each fluid transporting fractal extending along and about a central axis between fluid inlet and a plurality of fluid outlets; wherein each fluid transporting fractals comprises of a series of recursive bifurcation units assembled in a selected number of stages, each bifurcation unit comprising a Y-shaped bifurcated element which is fluidly connected to two successive bifurcation units, each successive bifurcation unit being rotated relative to the central axis by an angle of between 60 and 120 degrees relative to the previous stage; each fluid transporting fractal is intertwined with the other fluid transporting fractal; each fluid transporting fractal is positioned offset from the other fluid transporting fractal about the central axis and are arranged such that each fluid outlet from one of the fluid transporting fractals is located adjoining a fluid outlet of the other fluid transporting fractal, and each fluid transporting fractal is centered about a flow axis which is laterally inclined from greater than 0 to 20 degrees from the central axis and longitudinally inclined from greater than 0 to 20 degrees from the central axis.

A sparger assembly for a bioprocessing system includes a first layer having a plurality of pores of a first size, and a second layer disposed above the first layer and having a plurality of holes of a second size, the second size being greater than the first size. The pores of the first layer and the holes of the second layer allow for the passage of a sparge gas through the first layer and the second layer.

In an agitator in which cavitation arising during treatment of a fluid being treated is suppressed, a stator part S is provided with a plurality of penetration parts in the circumferential direction of the stator part S, and a stator main part positioned between adjacent penetration parts. When a fluid is discharged from the inside of the stator part S to the outside through the penetration part by the rotation of a rotor, in the stator part S for the agitator treating the fluid, the side facing a blade of the rotor is an inner wall surface, the side facing a blade of the rotor is an inner wall surface, the side facing the side opposite to the blade of the rotor is an outer wall surface, an opening of the plurality of penetration parts that is provided in the inner wall surface is an inflow opening, and an opening of the plurality of penetration parts that is provided in the outer wall surface is an outflow opening, the opening area of the inflow opening being larger than the opening are of the outflow opening.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

A propeller for a digestion tank mixer. The propeller has a hub and at least two blades. Each blade has an outer geometrical plane parallel to a center axis, perpendicular to a radius of the propeller, intersecting both a leading edge and a trailing edge of the blade, and an inner geometrical plane parallel to the outer geometrical plane and tangent to the hub. Each intermediate geometrical plane of the blade has an arc-shaped cross section extending between the leading edge and the trailing edge, and a chord extending between the leading edge and the trailing edge. An angle between the chord and a radial plane of the propeller is 25-45 degrees in each intermediate geometrical plane. The ratio between an arc-height between the chord and the thrust side surface, and the length of the chord, is 0.08-0.15 in each intermediate geometrical plane.

A multi-layered micro-channel mixer includes a base plate and a cover plate. Two inlet fluid reservoirs, two inlet channels, two groups of fluid distribution channel networks, two groups of process fluid channels, an impinging stream mixing chamber, a fluid mixing intensification channel and an outlet buffer reservoir are provided on the base plate. Two fluids are fed into the two inlet fluid reservoirs, respectively. The fluids then flow into the process fluid channels via the inlet channels and the multi-stage fluid distribution channel networks, respectively. Then the two fluid streams ejected from the opposing process fluid channels impinges upon each other in the impinging stream mixing chamber. The mixed fluid is subjected to vortex or secondary flow generated by the baffles or the internals in the impinging stream mixing chamber and fluid mixing intensification channel, and finally the mixed fluid is discharged through the outlet buffer reservoir.