The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidisation device whose interaction chamber comprises a plurality of Z-type channels upstream of a back pressure chamber.

Bioreactors are disclosed that include a vessel, a jet mixing system comprising a plurality of jet flow agitators disposed in the vessel, each jet flow agitator comprising a shaft, a shroud surrounding the shaft, the shaft having a bore and a plurality of orifices in communication with the bore, and an impeller mounted on the shaft within the shroud, and a gas delivery system configured to supply a process gas to the vessel through the bore such that the gas exits the orifices. The vessel may include a vent, and the gas delivery system may include a source of oxygen in communication with the vessel, an oxygen monitor configured to monitor the oxygen content of a liquid in the vessel, and a controller configured to adjust the oxygen content of the liquid, using the vent and oxygen source, in response to input from the oxygen monitor.

The invention addresses the problem of providing a method for producing microparticles. Provided is a method for producing microparticles. For the first process, seed microparticles are separated in a thin film fluid that forms between at least two processing surfaces, which are disposed facing each other, which can approach or separate from each other and at least one of which rotates relative to the other, and the fluid comprising the separated seed microparticles is discharged as a discharge fluid. Subsequently, for the second process, the separated seed microparticles are grown in the discharged discharge fluid to obtain the intended microparticles. Uniform and homogeneous microparticles are obtained as a result of the microparticle producing method comprising the two process.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

Herein disclosed is a system for producing an organic, the system including at least one high shear mixing device having at least one rotor and at least one stator separated by a shear gap, wherein the shear gap is the minimum distance between the at least one rotor and the at least one stator; a pump configured for delivering a fluid stream comprising liquid medium and light gas to the at least one high shear mixing device, wherein the at least one high shear mixing device is configured to form a dispersion of the light gas in the liquid medium; and a reactor comprising at least one inlet and at least one outlet, wherein the at least one inlet of the reactor is fluidly connected to the at least one high shear mixing device, and wherein the at least one outlet is configured for extracting the organic therefrom.

The present invention is a composting bioreactor system that can be continually fed with biodegradable solid wastes, waste waters and exhaust gases, that can automatically recycle the biodegradable wastes into liquid nutrients and heat energy, and that automatically supplies the nutritious liquid and heat into the integrated hydroponics system or aquaponics system. The invention together with the integrated food growing system can be installed onsite in places such as household balconies, household backyards and premises of restaurants and food factories etc. therefore can lead to zero mileage targets both for recycling the wastes and for growing the foods consumed in the same location. It can fully recover and reuse all the nutrients and heat energy from the treated wastes. It can also reach the target of nearly zero pollution to the environment during all processes. For better operational efficiency, an oblique cone agitator, a fish plow agitator and a vortex flower turbine are specially designed for the bioreactor system.

Systems, devices, and methods for the delivery of gas bubbles to liquids are generally described. The devices can include a primary conduit (102) comprising a plurality of openings (104) fluidically connecting an internal flow pathway (106) of the primary conduit to an environment outside the primary conduit. The devices may also include, in some instances, a secondary conduit (114) located at least partially within the primary conduit, the secondary conduit configured to redistribute the pressure of the gas delivered to the openings of the primary conduit, and comprising a plurality of openings (116) fluidically connecting an internal flow pathway (118) of the secondary conduit to a portion of the internal flow pathway (106) of the primary conduit outside the secondary conduit. Certain of the gas delivery systems and methods described herein are capable of delivering gas at relatively uniform linear flow velocities across multiple gas outlet openings. Certain embodiments are related to inventive configurations (e.g., spacings and/or sizing) of gas outlet openings in one or more conduits of the gas delivery device (e.g., the primary conduit and/or, when present, the secondary conduit). In addition, some embodiments are related to inventive arrangements for joining a gas delivery device is to a vessel, which may be part of for example, a reactor such as a bioreactor. Certain embodiments are related to the orientation of the gas delivery device and/or its components (e.g., during operation).

Herein disclosed is a system for producing an organic, the system including at least one high shear mixing device having at least one rotor and at least one stator separated by a shear gap, wherein the shear gap is the minimum distance between the at least one rotor and the at least one stator; a pump configured for delivering a fluid stream comprising liquid medium and light gas to the at least one high shear mixing device, wherein the at least one high shear mixing device is configured to form a dispersion of the light gas in the liquid medium; and a reactor comprising at least one inlet and at least one outlet, wherein the at least one inlet of the reactor is fluidly connected to the at least one high shear mixing device, and wherein the at least one outlet is configured for extracting the organic therefrom.

Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.