A method for producing a masterbatch includes feeding (e.g., continuously feeding) a first composition containing an elastomeric latex (e.g., a natural rubber latex) to a coagulation chamber; and feeding (e.g., continuously feeding) a second composition containing a particulate filler (e.g., carbon black) to the coagulation chamber. The carbon black is fed directly from a sonication chamber to the coagulation chamber and/or a sonication device facilitates ultrasonic mixing within the coagulation chamber. The first composition and the second composition are mixed in the coagulation chamber to form the masterbatch. The second composition may be fed to the coagulation chamber at a pressure of at least about 300 psig and/or a velocity of at least about 100 feet per second. The masterbatch may be dry mixed with an additional elastomer to form an elastomeric composite blend.

The present invention provides a method of preparing a lipid nanoparticle dispersion using a twin screw extruder. The inventive DNLF fluids are isotropic fluids which include greater than 25% lipophilic content in the form of lipidic nanoparticles dispersed in a continuous aqueous matrix with turbidity less than 375 nephelometric turbidity units (NTU).

A dry powder kneading apparatus includes a main body including an inner space into which a mixture containing an active material, a conductive material, and a binder is supplied, and a screw inside the inner space of the main body, the screw being configured to move the mixture in one direction and to knead the mixture into fiberized dry powder, and a rotation torque of the screw being 1.4 kgf.Math.m to 42 kgf.Math.m.

Provided is a mixing apparatus. The mixing apparatus comprises a housing defining a primary chamber, an inlet for receiving material into the mixing apparatus, as well as an outlet for discharging material from the mixing apparatus. The housing provides within the primary chamber a plurality of rotating shafts, each rotating shaft having a plurality of flailing fixtures associated therewith.

A feed stock-to-vermicast converter, comprising an enclosed flow-through vessel having an upstream inlet for introducing convertible feed stock into a mixed epigeic bed conversion zone adapted to accommodate a population of epigeic vermicast-producing worms, communicating with a vermicast-converted feed stock outlet.

A dispersing unit for dispersing a feed material in a dispersant, including a stationary dispersing basket, the lateral surface of which has outlet openings and one end of which is preferably at least partly closed and into which a shaft stub of a drive shaft protrudes, wherein, within the dispersing basket, the shaft stub bears a dispersing disk, which rotates during operation and thereby sucks feed-material-laden dispersant into the region between the dispersing disk and the closed end of the dispersing basket and discharges the feed-material-laden dispersant from said region largely via the outlet openings in the lateral surface of the dispersing basket

Embodiments of the present disclosure include a process and a system for solubilizing a surfactant in supercritical carbon dioxide that include providing a turbulent flow of the supercritical carbon dioxide into which the surfactant solubilizes and injecting the surfactant into the turbulent flow of the supercritical carbon dioxide to achieve a Jet Mixing Number of 0.01 to 1.0. In one or more embodiments, a pump provides turbulent flow to supercritical carbon dioxide moving through at least a portion of piping, and an injector associated with the piping conveys the surfactant through surfaces defining a port in the injector to inject the surfactant into the turbulent flow of the supercritical carbon dioxide so as to achieve the Jet Mixing Number of 0.01 to 1.0.

The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.