Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.

Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.

Hybrid microparticle having a polymer core and a shell which surrounds the polymer core at least in sections and which has a silicon dioxide layer; characterized by an RF value, the RF value being defined as the ratio of an external surface area amenable to the adsorption of nitrogen to a surface area which is computable from an arithmetic mean diameter of the hybrid microparticle considered as an ideal sphere, where the shell has a structure selected from: closed and smooth, with the shell having an RF value of between 1 and 1.5; closed and hillocky, with the shell having an RF value of between 1.51 and 3; or open, with the shell having an RF value of greater than 3.01.

A device for binding and separation of at least one component from a body fluid is disclosed. The device may have a proximal end and a distal end. The device may include a housing, an inlet disposed at the proximal end, an outlet, at least one of a sheet and a disc of a first matrix for binding of a first component from the body fluid, and a plurality of beads of a second matrix for binding of a second component from the body fluid. The first matrix may have a porous structure. The first component and the second component may be one of the same and different.

Provided are a toxin separator and the like which are capable of selectively separating toxin present in a biological fluid by binding to protein, from the toxin and the protein. The toxin separator of the present invention also includes activated carbon of which a pore volume of pores having a pore diameter from 1.4 to 35 nm as measured by a nitrogen adsorption method is 0.06 cm.sup.3/g or greater.

The present invention relates to a process for continuous purification of yellow phosphorus by adsorption onto activated carbon.

A protein-binding product comprising one or more porous polymer beads, wherein at least one ligand is bound to the surfaces of said polymer beads via a spacer (R), and wherein said at least one ligand is Gal1-3HexNAcO, Gal1-4GlcNAcO and/or a derivative thereof, is disclosed as well as a device containing said protein-binding product and a method for reduction of the level of at least one galactose-binding protein and optionally at least one other protein in human blood plasma.

The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

A filter system for filtering a fluid stream is disclosed herein. The filter system includes a first fluid passage, a first chamber, a second chamber, an adsorbing media, and a second fluid passage. The first fluid passage is arranged such that a fluid stream can flow through the first fluid passage and into the filter system. The first chamber is arranged to hold suspended or dissolved solids, pollutants, and nutrients that are filtered from the fluid stream. The second chamber is positioned above the first chamber and in fluid communication with the first chamber. The adsorbing media is positioned in the second chamber. The second fluid passage is arranged such that filtered fluid from the fluid stream can flow out of the filtering system through the second fluid passage.

A method for producing biochar aggregate particles that comprising the steps of (i) collecting or producing treated biochar fines less than 1 mm, (ii) adding a binding agent to the fines, (iii) forming the fines and binding agent into solid aggregate particles. The steps may further include, for example, adding additives to the fines, drying the solid aggregate particles, activing the binder after forming the solid aggregate particles with heat or cold temperatures and/or treating the biochar fines prior to forming the aggregate particles.