The invention relates to the use of a microdevice for the modification of protein with carbohydrate. Preferably for the glycation of protein with a mono-, di-, oligo- or polysaccharide(s). The invention also relates to the process for modifying protein with carbohydrate in a microdevice. The invention also relates to a process for preparing a food, feed, personal care, cosmetic, pharmaceutical, paper or corrugated board product comprising the process steps to prepare the modified protein and the step of combining the modified protein with at least one other ingredient.

The present invention relate to a reactor comprising: (i) a first reagent release mechanism, (ii) a second reagent release mechanism, and (iii) a reaction area fluid pathway, wherein the reaction area fluid pathway comprises a pathway extension valve, wherein adjusting the pathway extension valve varies the length of the reaction area fluid pathway, and wherein the pathway extension valve comprises a single valve.

A method is for synthesizing an oxetane compound by a microreactor. The synthesis method includes: introducing trimethylolpropane and carbonate into the microreactor in the presence of an alkaline catalyst, and synthesizing the oxetane compound by means of a micro-reaction continuous flow process under an inert solvent or a solvent-free condition. Compared with conventional reactors, the microreactor has the advantages of being high in heat transfer mass transfer coefficient, good in mixing performance, easy to control in temperature, safe and controllable in process. The three oxetane products are produced by utilizing the advantages of the microreactor, thereby greatly improving the mass transfer heat transfer performance of a reaction system, shortening the reaction time, improving the production efficiency, particularly avoiding the long-time high-temperature process in the pyrolysis process, reducing the production of high-boiling-point by-products, improving the yield, realizing continuity and automation of the process, and improving process safety.

The present invention concerns the field of microreaction devices and of micro-process engineering. It particularly involves devices having micro-channels (internal chambers of micrometric to submicrometric dimensions) for conveying chemical or biochemical mixtures and/or reactions. More specifically, such devices are optimized to achieve high temperature and pressure stresses (i.e. 500° C. and 500 bar). For observation and analysis purposes, the microreaction devices have a wide range of transparency in terms of wavelengths. The subject matter of the present invention relates to a microfluid or microreactor device made of transparent sapphire, preferably in the wavelength range of 150 to 6500 nm, its manufacturing method and to its use.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

A microfluidic device includes a channel through which a reaction solution flows. The channel passes through a reaction section having a plurality of temperature zones set at predetermined different temperatures. The channel includes, at least in the reaction section, a region where a cross-sectional area decreases in a feeding direction of the reaction solution.

A channel assembly is disclosed, which may comprise a microfluidic channel. Methods of manufacture are also disclosed as are detectors and detector components which may comprise such a channel assembly. An example is a detection apparatus comprising: a detector for detecting a substance of interest; and a pneumatic system comprising a microfluidic channel assembly comprising a first microfluidic channel for dispensing vapour to the detector, wherein the first microfluidic channel comprises a groove in a surface of a polymer body and a wall of the first channel is provided by a film bonded to the surface of the body over the groove.

Disclosed herein are methods for preparing nanomaterials, such as nanoparticles. The methods can involve jet-mixing two or more precursor solutions to form the nanomaterials. By rapidly mixing the precursor solutions, nanomaterials of improved quality and uniformity can be prepared in high yield (e.g., in yields of at least 85%). The methods are also scalable, and allow for the continuous production of nanomaterials. Also provided are jet-mixing reactors that can be used to prepare nanomaterials using the methods described herein.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

Microfluidic devices having superhydrophilic bi-porous interfaces are provided, along with their methods of formation. The device can include a substrate defining a microchannel formed between a pair of side walls and a bottom surface and a plurality of nanowires extending from each of the side walls and the bottom surface. For example, the nanowires can be silicon nanowires (e.g., pure silicon, silicon oxide, silicon carbide, etc., or mixtures thereof).