Microfluidic systems and methods are described for capturing magnetic target entities bound to one or more magnetic beads. The systems include a well array device that includes a substrate with a surface that has a plurality of wells arranged in one or more arrays on the surface. A first array of wells is arranged adjacent to a first location on the surface. A second and subsequent arrays, if present, are arranged sequentially on the surface at second and subsequent locations. When a liquid sample is added onto the substrate and caused to flow, the liquid sample will flow across the first array first and then flow across the second and subsequent arrays in sequential order. The wells in the first array each have a size that permits entry of only one target entity into the well and each well in the first array has approximately the same size.

The present invention relates to a device (1) for filtering a fluid circulating in a plumbing and heating system, comprising a body (2) defining therewithin a filtration chamber (3) that is destined to have a fluid to be subjected to filtration pass through it. The body is provided with a first inlet/outlet opening (10), a second inlet/outlet opening (20) and a third inlet/outlet opening (30): each of which sets the filtration chamber (3) in communication with the outside of the device and can be associated with a line of the system to receive therefrom, or send thereto a fluid entering or exiting said body of the device. The device operates a passage of fluid through the filtration chamber (3), in a selective manner according to a plurality of operative configurations, from an opening between said first (10), second (20) and third inlet/outlet opening (30) to a further opening between said first, second and third inlet/outlet opening. The device further comprises filtering members (40) housed inside the filtration chamber and interposed between the inlet/outlet openings to perform filtering of the fluid passing through the filtration chamber; the filtering members comprise a mechanical filter (41) arranged in the filtration chamber and structured so as to divide the filtration chamber into a first sub-chamber (A), a second sub-chamber (B) and a third sub-chamber (C), in which the first sub-chamber is in fluid communication, without passing through the mechanical filter, with the first inlet/outlet opening, the second sub-chamber is in fluid communication, without passing through the mechanical filter, with the second inlet/outlet opening, and the third sub-chamber is in fluid communication, without passing through the mechanical filter, with the third inlet/outlet opening.

The present invention relates to a device (1) for the filtration of a fluid circulating in a plumbing and heating system, comprising a body (2) of the device defining therein a filtration chamber (3) and equipped with: filtration members (40), to perform a filtration of the fluid passing through the filtration chamber (3), comprising a filtering element (41) which divides the filtration chamber into a first (8) and a second half-chamber (9); an inlet/outlet interface (10) having a first inlet/outlet opening (11), in communication with the first half-chamber, and a second inlet/outlet opening (12), in communication with the second half-chamber. The device comprises a connection module (30) which can be mounted on the body of the device and comprising: a first inlet/outlet conduit (31) and a second inlet/outlet conduit (32), configured to be associated with respective pipes of a heating system; a connection interface (33) that can be selectively associated with the inlet/outlet interface of the body of the device; a first passage section (34), defined on a portion of the connection interface and in fluid communication with the first inlet/outlet conduit; a second passage section (35), defined on a respective portion of the connection interface and in fluid communication with the second inlet/outlet conduit. The connection module (30) is configured to be selectively mounted on the body (2) of the device according to a plurality of different operative configurations.

A temperature-controlled tramp metal separation assembly includes a core rod and a magnetic set. The core rod is made of non-magnetic materials and includes a chamber, a first end with an air inlet, and a second end with an air outlet. The magnetic set includes a plurality of magnetic members and a plurality of spacers respectively disposed between the two adjacent magnetic members. The magnetic set is nested in the chamber in a way that an air path is formed therein so that an external cooling air flow can be introduced from the air inlet, and then discharged from the air outlet via the air path. Thus, the operating temperature of the tramp metal separating process can be maintained at an acceptable level, preventing the magnetic force of the magnet set from being reduced.

The present disclosure describes a filtration device that includes a housing that includes a first tubular section connected to a second tubular section, wherein the first tubular section extends along a longitudinal axis and includes an open end that forms a fluid inlet of the housing, a closed end opposite the open end, and a connection opening positioned between the open and closed ends, and wherein the second tubular section includes a first open end connected to the connection opening of the first tubular section and a second open end that forms a fluid outlet of the housing; and a filter that is arranged inside of the first tubular section and that extends along the longitudinal axis of the first tubular section; wherein the filter includes an electromagnet configured to generate a magnetic field that surrounds at least the first tubular section and attracts metal contaminants in a fluid to the filter. A filter system is also described.

A sorting apparatus is provided for sorting selected magnetically attractable articles from non-selected magnetically attractable articles in a stream of articles. A sensor generates sensor signals representative of a property associated with a selected class of magnetically attractable articles. A separator device includes an array of magnets. A controller receives sensor signals from the sensor, identifies a location within the stream of articles of a selected magnetically attractable article, and selectively activates one or more magnets of the array of magnets and thereby magnetically attracts the selected magnetically attractable article from a first trajectory into a second trajectory while allowing non-selected magnetically attractable articles to continue along the first trajectory.

A sorting apparatus is provided for sorting selected magnetically attractable articles from non-selected magnetically attractable articles in a stream of articles. A sensor generates sensor signals representative of a property associated with a selected class of magnetically attractable articles. A separator device includes an array of magnets. A controller receives sensor signals from the sensor, identifies a location within the stream of articles of a selected magnetically attractable article, and selectively activates one or more magnets of the array of magnets and thereby magnetically attracts the selected magnetically attractable article from a first trajectory into a second trajectory while allowing non-selected magnetically attractable articles to continue along the first trajectory.

Magnetic systems and methods for oxygen separation and purification from fluids utilizing the paramagnetic properties of oxygen. A magnetic field gradient is established in a tube having a first end in flow communication with a source of a fluid containing oxygen. The fluid is flowed through the tube. The magnetic field gradient causes oxygen to be enriched in the fluid on a first interior side of the tube as compared to a second interior side of the tube. For a fluid like air having oxygen, a paramagnetic substance, and other, e.g., diamagnetic, components like nitrogen, argon, carbon dioxide and water vapor, the technology of the disclosure effectively separates oxygen molecules from the other components in magnetic field gradients of sufficient magnitude.

The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.

A holder that can be used to stand up a PCR tube on a flat surface or held in a user's hand. The holder has a first elongated portion, a second elongated portion and a third elongated portion. The first elongated portion having a magnet, the second elongated portion having a tube holding means and the third elongate portion acting as a stabilizer to allow the holder to standup in an upright position. The third elongate portion can also be used as a gripping surface to be held between fingers of a hand.