A spray nozzle chip comprising: a first layer provided with a first layer orifice, and a mechanically flexible nozzle layer provided with a nozzle orifice, wherein the first layer has a valve seat arranged aligned with the nozzle orifice, wherein the spray nozzle chip has a valve functionality obtained by movement of the nozzle layer relative to the valve seat due to pressure changes, and wherein the nozzle layer is arranged at a distance from the valve seat when the nozzle layer is in a default non-pressurised state, whereby a gap with a gap length (L) is formed between the nozzle layer and the valve seat, wherein the gap length (L) is smaller than a dimension of a specific bacterial type, to thereby seal against bacterial ingrowth through the nozzle orifice of the specific bacterial type.

The present invention provides for a method for the treatment of a respiratory disease, disorder or condition, or a viral infection or viral disease, disorder or condition in a subject, the method comprising the step of administering to said subject a medically active liquid in nebulized form by inhalation, wherein the medically active liquid comprises niclosamide or a pharmaceutically acceptable salt thereof and wherein the medically active liquid is administered in nebulized form using an inhalation device.

A cartridge for a dispensing device, such as a nebulizer, for dispensing a medicament composed of or produced from a plurality of components and a system including a dispensing device, such as a nebulizer, and such a cartridge. The cartridge includes at least two fluidically separated chambers which each contain at least one component of the medicament, an actuating mechanism for fluidically connecting the chambers and mixing the components for the dispensing of the medicament A method for preparing a medicament composed of a plurality of components in a cartridge for the dispensing of said medicament by way of a dispensing device, such as a nebulizer, where a plurality of fluidically separated chambers of the cartridge are fluidically connected, and a component of the medicament is at least partially transferred from one of the chambers to another of the chambers with another component of the medicament in order to mix the components. Only once the components have been mixed is the cartridge opened for the extraction of a dose of the medicament.

A fluid dispenser device comprising: a reservoir (10) containing one or more doses of fluid; a resilient element (20), such as a spring, for urging said reservoir (10) to move axially between a rest position and at least one actuated position; and blocking means (30; 51, 53, 55) for preventing said reservoir (10) from moving axially; said blocking means being movable manually in a direction that is different from the direction of said axial movement of the reservoir (10) so as to allow said reservoir (10) to move axially; said blocking means comprising a plate (30) provided with an opening (31) comprising a first opening portion (31a) of smaller size, and a second opening portion (31b) of larger size, said first and second opening portions (31a, 31b) being interconnected, said plate (30) being movable radially between a blocking position in which said first opening portion (31a) co-operates with said reservoir (10) so as to block it axially, and a non-blocking position in which said second opening portion (31b) co-operates with said reservoir (10) so as to allow said reservoir (10) to move axially under the effect of said resilient element (20).

A system includes a nebulizer for nebulizing a fluid from a container and such a container containing a fluid and are proposed. The fluid is a non-newtonian fluid, in form of a suspension or emulsion or a liposomal fluid or a gel. The nebulizer includes a fluid pump for withdrawing the fluid in doses from the container and pressurizing the respective doses for nebulization through nozzle channels having a hydraulic diameter in the range of 3 to 20 microns at an operational pressure of 5 to 250 MPa.

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a liquid emission mechanism for an inhalation device, as well as a method of emitting a liquid from an inhalation device. The inhalation device comprises a housing (1), a reservoir (2) for storing a liquid, a pumping unit, said unit comprising a riser pipe (5), a hollow cylindrical part (3) having an interior space and being linearly moveable on the riser pipe (5), wherein the pumping chamber is fluidically connected with the reservoir (2), and a nozzle (6) which is connected liquid-tight to an downstream end portion (5B) of the riser pipe (5), and wherein said linear relative motion can be effected by a relative rotation around a rotational axis (R) of a rotatable part (1A) with respect to a counterpart (1B), such that said relative rotation is converted into said linear relative motion by means of a gear mechanism comprising at least one cam surface having a first section (9A) and a second section (9B), and wherein a means for the storage of potential energy (7) is provided. The device is characterized in that said cam surface has, between the first section and the second section (9A, 9B), a third section (9C) of constant height, such that, while said counterpart (1B) slides along said third section (9C), no linear relative motion occurs. A method for the generation of an aerosol comprises, upon rotation of the rotatable part (1B), a first, charging phase for filling the pumping chamber with liquid, and a second, discharging phase for emitting the atomized liquid from the nozzle (6), and is characterized in that between said two phases, a third, resting phase exists during which, despite further rotation, the volume of the pumping chamber remains constant.

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device for delivering a nebulised medically active aerosol for inhalation therapy comprising a pumping unit, said pumping unit comprising a riser pipe (2), a hollow cylindrical part (3) having an interior space configured to receive an upstream end portion (21) of said riser pipe (2), said cylindrical part (3) being moveable on the riser pipe (2), wherein the cylindrical part and the riser pipe form a pumping chamber having a variable volume, wherein a gap (4) is present between a lateral outside surface (22) of the upstream end portion (21) of said riser pipe (2) and a lateral internal surface (31) of said cylindrical part (3), wherein a seal (1) is present between the outside surface (22) of said riser pipe (2) and the internal surface (31) of said cylindrical part (3), thus physically bridging said gap (4), and wherein the seal (1) has a cap-like shape configured to fit around the upstream end portion (21) of the riser pipe (2), having at least one opening (11) for providing a fluid connection between an interior space of said riser pipe (2) and said pumping chamber, and wherein at an interior surface (14) of the seal (1), at least one interior protrusion (16) is present which is configured to be received by at least one respective recess (23) of the riser pipe (2).

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.

An inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), an impingement-type nozzle (6) for generating the nebulised aerosol by collision of at least two liquid jets, the nozzle (6) being firmly affixed to the user-facing side of the housing (1) such as to be immobile relative to the housing (1), inside the housing (1) the inhalation device comprises a reservoir (2) for storing a liquid (F), a pumping device with a pumping chamber (3) for generation of a pressure inside said pumping chamber (3), wherein the pumping chamber (3) is fluidically connected with the reservoir (2), a riser pipe (5) which can be received with at least one reservoir-facing, interior end (5A) in said pumping chamber (3), and said nozzle (6) which is connected liquid-tight to an exterior end (5B) of the riser pipe (5), wherein the interior volume of the pumping chamber (3) is changeable by means of relative motion of the pumping chamber to the riser pipe (5) or vice versa.

A gap (10) can be present between an outside of said riser pipe (5) and an inside of said pumping chamber (3), and a seal (9) bridging said gap (10) in order to minimize pressure loss when a pressure is generated inside said pumping chamber (3).

Said seal (9) can be fixed to said outside of said riser pipe (5), and be moveable with respect to said inside of said pumping chamber (3).

A cartridge and a nebulizer for nebulizing a fluid as well as a method for fluidically connecting the cartridge to the nebulizer are proposed. The cartridge comprises a closure with a valve, wherein the valve displaces fluid into the nebulizer when opened. Further, the cartridge forms two axially spaced sealings with the nebulizer when connected.

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of a medically active liquid by means of such inhalation device.

An inhalation device comprises a housing (1), inside this housing (1) at least one reservoir (2) for storing a liquid (F, F1, F2), at least one pumping unit with at least one pumping chamber (3, 3A, 3B) for generation of a pressure inside said pumping chamber (3, 3A, 3B), at least one riser pipe (5, 5A, 5B) which can be received with at least one reservoir-facing, interior end (5A′, 5B′) in said pumping chamber (3, 3A, 3B), and a nozzle (6) which is connected to an exterior end (5A″, 5B″) of the riser pipe (5, 5A, 5B), wherein the interior volume of the at least one pumping chamber (3, 3A, 3B) is changeable by means of relative motion of the pumping chamber (3, 3A, 3B) to the riser pipe (5, 5A, 5B), and wherein the at least one riser pipe (5, 5A, 5B) is immobile and firmly attached to the housing (1) or to the nozzle (6), and the at least one pumping chamber (3, 3A, 3B) is moveable relative to the housing (1) or to the nozzle (6), wherein further, the nozzle (6) has a main axis (Z) and at least three ejection channels (6A, 6B, 6C, 6D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least one collision point (X, X1, X2) is provided at which at least two of said ejection trajectories intersect with one another.