Provided herein are processes for recovering lithium ions from a brine source. The process can comprises increasing the pH of a brine source comprising lithium ions to at least about 5.5; contacting the pH-elevated brine source with a bed of protonated ion exchange media to produce a lithiated ion exchange media and a lithium-depleted brine stream; contacting the lithiated ion exchange media with an acidic aqueous wash liquid; and contacting the washed lithiated ion exchange media with an elution liquid comprising an acid. Also provided herein is a process for increasing the pH of brine comprising obtaining brine from a brine source comprising lithium ions; adding the brine to a continuously stirred tank reactor without preprocessing the brine to remove solid matter; adding a strong base to the continuously stirred tank reactor; contacting the brine with the base. Further provided herein are processes for creating a lithiated ion exchange media, which can comprise contacting a pH-elevated brine source with a bed of protonated ion exchange media; and producing a lithiated ion exchange media and a spent brine, wherein the bed of protonated ion exchange media comprises a metal oxide absorbent and a polymeric binder.

A method of recovering a sugar by separating a fermentation inhibitor and the sugar from a sugar solution containing the fermentation inhibitor, the method including: bringing the sugar solution containing the fermentation inhibitor into contact with a basic anion exchange resin filled into a column, followed by separation of the fermentation inhibitor and the sugar by a difference in retention time therebetween through use of water as an eluent, and separate recovery of a fraction containing the fermentation inhibitor and a fraction containing the sugar, wherein the basic anion exchange resin is previously treated with a solution containing the fermentation inhibitor.

Disclosed is a natural compound sweetener, comprising mogroside V, rebaudioside A, natural tea theanine and dietary fibre. The method for preparing the sweetener comprises the steps of: (1) dissolution, filtration, concentration and sterilization: dissolving the mogroside V, rebaudioside A, natural tea theanine and dietary fibre in water, filtering, concentrating in a vacuum, and sterilizing to obtain a sterilized solution; and (2) paste-collection, drying and granulation: carrying out paste-collection on the sterilized solution obtained in the step (1), vacuum drying the collected liquid paste, and drying and then granulating the dry powder to obtain the sweetener.

Provided herein are methods of separating host cell lipases from an anti-LAG3 antibody or antigen binding fragment in chromatographic processes and methods of improving polysorbate-80 stability in an anti-LAG3 antibody formulation by separating host cell lipases from the anti-LAG3 antibody or antigen binding fragment using chromatographic processes. Also provided are pharmaceutical compositions comprising an anti-LAG3 antibody or antigen binding fragment and less than 2 ppm of a host cell lipase.

Provided herein are methods of separating host cell lipases from an anti-LAG3 antibody or antigen binding fragment in chromatographic processes and methods of improving polysorbate-80 stability in an anti-LAG3 antibody formulation by separating host cell lipases from the anti-LAG3 antibody or antigen binding fragment using chromatographic processes. Also provided are pharmaceutical compositions comprising an anti-LAG3 antibody or antigen binding fragment and less than 2 ppm of a host cell lipase.

Method for lowering aldehyde content in a mixture comprising (i) diethylene glycol (DEG) and/or triethylene glycol (TEG) and (ii) aldehyde are disclosed. An ion exchange resin is soaked in monoethylene glycol. The mixture comprising 5 to 200 ppm aldehyde is then flowed to make contact with the soaked ion exchange resin to produce a product comprising DEG and/or TEG and less than 15 ppm aldehyde.

A process for the purification of an aqueous hydrogen peroxide solution includes the following steps: (a) the treatment of an aqueous hydrogen peroxide solution with at least one first reverse osmosis system, (b) the treatment of the obtained hydrogen peroxide solution with at least one first stabilizer, (c) the treatment of the obtained hydrogen peroxide solution with at least one purification mean selected from adsorption resins, ion exchange resins, and combinations thereof.

An aqueous hydrogen peroxide solution obtainable thereby is described. The use of the aqueous hydrogen peroxide solution in the manufacture of microelectronic components and semiconductors is also described.

A filter cartridge assembly for an ice making appliance having a rectilinear filter cartridge with a plurality of partitions that are positioned within an internal chamber, form multiple sub-chambers, and create a non-linear pathway for the flow of water through the filter cartridge. Filter media positioned in the sub-chambers of the filter cartridge are configured to remove dissolved solids from water travelling through the filter cartridge and used by the appliance to create ice, including clear ice.

In a method for facilitating selection of chromatography parameters for manufacturing a therapeutic protein, one or more process parameter values associated with a hypothetical chromatography process, and one or more molecular descriptors descriptive of the therapeutic protein, are received. The method also includes predicting a performance indicator for the hypothetical chromatography process at least by analyzing the one or more process parameters and the one or more molecular descriptors using a machine learning model. The machine learning model is a regression tree model, an extreme gradient boost model, or an elastic net model. The method also includes causing the predicted performance indicator, and/or an indication of whether the predicted performance indicator satisfies one or more acceptability criteria, to be presented to a user via a user interface.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.