A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.

Fermenter for producing a shear-thinning medium comprising a tank volume and a stirring arrangement having an improved distribution capacity or a more uniform shear stress.

Disclosed is a reactor for treating, particularly by hydrothermal carbonization, sludge containing organic matter, including, with: a vessel (100) including an inner chamber arranged to receive the sludge and to form a path of travel for the sludge adapted to allow for circulation of the sludge, a sludge inlet (1) arranged to introduce the sludge into a sludge introduction area of the inner chamber, a sludge outlet (11) arranged to discharge at least part of the sludge contained in the inner chamber, and a steam inlet (3) arranged to inject steam in a steam injection zone of the inner chamber along a steam injection direction, the steam injection direction being different from a sludge circulation direction in the steam injection zone along the circulation path, the steam injection zone being separated from the sludge introduction zone.

A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then vented, permitting the impeller to sink in the fluid. The floating impeller may be tethered to a second impeller with a flexible member and pulley. The mixing speed is controlled with electromagnets in the vessel acting upon magnetic material in the impeller or its guides. In another embodiment, floating pistons mix the fluid, pushing it through a mixing plate with one or more apertures. In a third embodiment, the mixing device is a rotating drum with bubble-catching blades and rotating mixing plates with apertures. The top of the vessel for these mixers may include a closed top and sterile filters.

Disclosed is a method for assembling a mixer-container intended for receiving a biopharmaceutical fluid in which: a container is provided, the container including: a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to the wall, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container is provided; a drive motor located outside the container is provided; the first bearing of the container is placed so as to be spaced apart from the motor; the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

The invention discloses an agitation device comprising an impeller, an agitating shaft and a power device. The impeller includes a disc, a hub and concave blades. Each blade consists of a concave surface which extends radially and has an annular sector-like shape, the projections of the upper and lower portions of the blade in the horizontal plane are two annular sectors, and the radian of the annular sector obtained by the projection of the upper portion is larger than that of the lower portion, and the annular sector-like shape and the rotation direction of blades are the same, so that each portion of the blades directly faces an incoming flow, the utilization efficiency of blades is increased and the impeller has low energy consumption and high gas-liquid dispersion efficiency. The device is efficient and energy-saving, has low power consumption, high mixing performance and high gas holdup and mass transfer performance.

An aeration device includes a pipe, connection members and a first connection unit which is connected to the connection member. The first connection unit includes a first connector, a first connection part, a one-way member, a second connector, a turbine unit and a shell. When air enters into the pipe, the shell guides the air and liquid in the pound into the turbine unit via the second and third rooms so as to increase the mixing feature of the air and the liquid in the pound.

Disclosed is a reactor for treating, particularly by hydrothermal carbonization, sludge containing organic matter, including, with: a vessel (100) including an inner chamber arranged to receive the sludge and to form a path of travel for the sludge adapted to allow for circulation of the sludge, a sludge inlet (1) arranged to introduce the sludge into a sludge introduction area of the inner chamber, a sludge outlet (11) arranged to discharge at least part of the sludge contained in the inner chamber, and a steam inlet (3) arranged to inject steam in a steam injection zone of the inner chamber along a steam injection direction, the steam injection direction being different from a sludge circulation direction in the steam injection zone along the circulation path, the steam injection zone being separated from the sludge introduction zone.

The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

A method and apparatus for injecting a gas into a liquid in which a rotating helical impeller within a draft tube submerged in the liquid creates a liquid flow within the draft tube. Gas bubbles are injected into the draft tube either above or below or alongside the helical impeller or in all three locations. The liquid is drawn into the draft tube with a superficial velocity greater than a substantially uniform terminal ascent velocity of the gas bubbles to allow entrainment of undissolved gas bubbles in the bulk liquid into the liquid being drawn into the draft tube. The gas bubbles are injected with a uniform diameter of between about 10.0 microns and about 1.0 millimeters. The small bubble size enhances the dissolution of the gas into the liquid and also allow the entrainment of the gas into the liquid being drawn into the draft tube.