An inline mixer device includes a flexible tube and a mixer portion. The mixer portion is internal to and integral with the tube. The mixer portion and tube may be comprised of the same flexible material. Methods of forming the inline mixer device are provided. Methods of mixing fluid with the inline mixer device are provided.

Disclosed are devices, systems, kits, and methods for controlling liquid flow and, e.g., in particular, for forming droplet having substantially uniform droplet-to-droplet content. The devices, systems, and kits may include a first channel including a funnel or may include a first channel and a first-side channel, the first channel being in fluid communication with a droplet formation region. The devices, systems, and kits may further include a second channel fluidically connected to the first channel or the first side-channel. Funnels and/or side-channels may be used to enhance the control over particle spacing in the channels, thereby providing superior control over the number of particles of the same kind in formed droplets. The devices, systems, and kits of the invention may further include a mixer downstream of a channel intersection. Mixers can be used to reduce localized pockets of high concentration of dissolved ingredients.

A flow cell for use in a fluid management and/or processing system is disclosed, said flow cell comprising a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet. Said body further comprises a receptacle comprising a chamber forming a part of the fluid flow channel, said chamber comprising a first opening for connecting a functional element to the flow cell such that the functional element is in contact with or exposed to a fluid flow passing through the fluid flow channel. A first tubular connector is arranged adjacent to the inlet. A second tubular connector is arranged adjacent to the outlet. The flow cell further comprises a functional element and a fluid flow path extending from the first tubular connector through the inlet, the body, the receptacle, and the outlet, to the second tubular connector.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Disclosed herein are continuous flow systems having bifurcated fluidic flow mixers. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). DVBMs utilize Dean vortexing and bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing.

A mixer for mixing a fluid solution, such as a diesel exhaust fluid for selective catalytic reduction, with a gas, such as an exhaust gas, includes a mixing chamber with a general cylinder shape obtained by translation of a polarly period section along a first axis. The fluid solution is sprayed in the mixing chamber by way of a first axial end thereof. The gas enters the mixing chamber through openings formed in a generatrix surface of said mixing chamber, and the mixture exits through a second axial end opposite the first axial end. The polarly period section is shaped in a star, obtained by polarly periodically repeating an elementary profile, comprising an opening defined by a first angle between a first segment passing through the two ends of said opening and a radial line passing through the distal end of said first segment.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

The present invention relates to a static mixer for mixing together at least two components. The static mixer comprises a mixer housing; a mixing element having an upstream end with at least two entry openings and a downstream end, the mixing element being arranged at least partly within the mixer housing; a mixing head having at least two inlets provided at an input side and at least two outlets provided at an output surface, wherein each of the at least two inlets is in fluid communication with one of the at least two outlets; and a separating wall disposed between the output surface and the upstream end of the mixing element for separating the components leaving the outlets. The separating wall comprises a free downstream edge which is disposed with respect to at least one of the entry openings so as to allow at least partial flows of the components separated by the separating wall to combine after exceeding the downstream edge and to jointly enter said at least one of the entry openings.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.