A mixer system comprising a sealed tube (2) provided with inlets and outlets (4,5) for a process fluid which is rotatable in arcs around the longitudinal axis of the tube (3) and contains one or more blades (11) mounted at each end on a blade carrier (10) supported within the tube (3) in a manner that allows the one or more blades (11) to rotate in the same direction and angular velocity (in degrees per second) as the tube (3) rotates in arcs and the use of such a system as a reactor and/or for mixing.

A static mixer for mixing a flow of two or more fluids is disclosed. The static mixer includes a mixing conduit that defines a mixing passage, and a mixing element configured to be received by the mixing passage that includes at least two mixing baffles. Each of the at least two mixing baffles comprises a plurality panels that are configured to divide and mix the fluid as the fluid flows through the mixing passage. No continuous sidewalls extend between the at least two mixing baffles, and the mixing element is tapered along a longitudinal direction.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.

Systems and techniques are described for capturing target extracellular vesicles from a fluid sample. In some implementations, a microfluidic device includes a microfluidic channel where an internal surface of at least one wall of the microfluidic channel includes a plurality of grooves or ridges, or both grooves and ridges, arranged and configured to generate chaotic mixing within a fluid sample flowing through the microfluidic channel. The microfluidic device also includes a plurality of elongate flexible linker molecules, each having a molecular weight between about 1.8-4.8 kDa, where each elongate flexible linker molecule is bound at a first end to an internal surface of at least one wall of the microfluidic channel and is bound at a second end to one or more binding moieties that specifically bind to a target extracellular vesicle.

A static mixer created using an additive process is disclosed. The static mixer is enabled to homogenously blend two fluids flowing in a pipe. The static mixer exhibits zero contact angle in relation to the two fluids being mixed within the pipe. The static mixer exhibits a first contact angle with the first fluid and a second contact angle with the second fluid. The first contact angle is either between 0 and 30 or greater than 85. The second contact angle is either between 0 and 30, or greater than 85.

A mixer system comprising a sealed tube (2) provided with inlets and outlets (4,5) for a process fluid which is rotatable in arcs around the longitudinal axis of the tube (3) and contains one or more blades (11) mounted at each end on a blade carrier (10) supported within the tube (3) in a manner that allows the one or more blades (11) to rotate in the same direction and angular velocity (in degrees per second) as the tube (3) rotates in arcs and the use of such a system as a reactor and/or for mixing.

A fluidic device includes a base structure, a wall structure, and a cover structure bounding a fluidic passage containing a functionalized active region of at least one bulk acoustic wave (BAW) resonator structure. One or more of the wall structure, the cover structure, or a portion of the base structure includes multiple features (e.g., protrusions and/or recesses) configured to interact with fluid flowing within the fluidic passage to promote mixing between constituents of the fluid. Methods for fabricating a fluidic device, as well as methods for biological or chemical sensing using a fluidic device, are further provided.

A mixing element for a static mixer for installation into a tubular mixer housing has a longitudinal axis along which at least one first and one second installation body are arranged behind one another. An inlet element is provided which is arranged upstream of the first installation body, wherein the inlet element and the first installation body are connected to one another via a connection element. The inlet element has a body which can be sealingly taken up at the peripheral side in the mixer housing. The body has a first inlet passage and a second inlet passage, wherein the first inlet passage has a first entry opening and a first exit opening, wherein the second inlet passage has a second entry opening and a second exit opening so that the corresponding component can be conducted through the corresponding inlet passage.

A static mixer for mixing a flow of two or more fluids is disclosed. The static mixer includes a mixing conduit that defines a mixing passage, and a mixing element configured to be received by the mixing passage that includes at least two mixing baffles. Each of the at least two mixing baffles comprises a plurality panels that are configured to divide and mix the fluid as the fluid flows through the mixing passage. No continuous sidewalls extend between the at least two mixing baffles, and the mixing element is tapered along a longitudinal direction.