A hemocompatible adsorber for separating protein-bound uremic toxins contained in the blood of a patient and having a molecular mass of <500 g/mol regarding their carrier proteins, to adsorb the uremic toxins during hemodialysis. The hemocompatible adsorber including a polymer based on a cyclic oligosaccharide or a derivative thereof which is disposed on a solid carrier component. A device for hemodiafiltration including an extracorporeal circuit for receiving blood to be purified and a hemodialyzer connected to the blood circulation of a patient, wherein a hemocompatible adsorber is provided for separating protein-bound uremic toxins contained in the blood of a patient and having a molecular mass of <500 g/mol regarding their carrier proteins. The hemocompatible adsorber, which is disposed on a solid carrier component in at least one layer on the blood side within the hemodialyzer, includes a polymer based on a cyclic oligosaccharide or a derivative thereof.

The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO.sub.2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries of the invention can be used in extraction and/or enrichment of samples to be analyzed for catecholamines and related compounds.

The present invention is directed to a ligated metal-organic framework (MOF) for use in removing both anionic and cationic species from a liquid or liquid stream. The present invention also provides methods for placing the MOF on a substrate to form a MOF-containing product that can be used in the removal of certain species from a given fluid. The MOF may be a Zr-based MOF, such as NU-1000, for removal of certain anions, such as oxy-anions, or having an attached thiosulfonyl-thiol (SO.sub.2SR.sub.2SH, where R.sub.2 is an alkyl group) ligand for complexation with certain cationic species in addition to the anions. The substrate may be any substrate to which a given MOF may be attached, including inert polypropylene polymer resin beads, a macroscopic fabric such as a mesh material or mesh filter, and a molecular fabric.

The present invention concerns methods of treating a patient suffering from a traumatic brain injury (TBI), comprising contacting said patient's blood with a sorbent for an inflammatory mediator and kits for performing such treatments.

Direct polymerization of lipid monomers or polymer scaffolding of non-lipid monomers coupled with irradiation or redox polymerization performed at neutral pH resulted in stabilized lipid assemblies. An initiator-buffer component and NaHS03 redox mixture polymerizes reactive lipid monomers at near neutral pH conditions to preserve functionality of reconstituted membrane proteins. Improved stability of black lipid membranes (BLMs) is attained by chemical cross-linking of polymerizable, hydrophobic and commercially available non-lipid monomers partitioned into the suspended lipid membranes, and by suspending the BLMs across low surface energy apertures. Substrate apertures having low surface energy modifiers with amphiphobic properties facilitated a reproducible formation of BLMs by promoting interactions between the lipid tail and the substrate material. In addition, polymeric lipid bilayer membranes were prepared by photochemical or redox initiated polymerization of polymerizable lipid monomers, and disposed onto supporting substrates for use in chromatography columns.

Microcapsules or macrocapsules have a core composition that includes a phase changing material (PCM) encapsulated within a polymer wall with an outer shell having a siloxane tethered to an exterior surface of the polymer wall by a surfactant. The siloxane may form a crystalline or a sol-gel outer shell. Methods of making such capsules and textile fabrics and clothing incorporating such capsules include treating pre-formed capsules with a surfactant solution followed by treating with a compound containing a siloxane functional group. The surfactant connects or tethers the siloxane to the exterior surface of the polymer wall and the siloxane forms an outer shell of the capsules.

Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Preparing a porous hybrid media includes contacting porous media (e.g., strong base ion-exchange media) with an aqueous solution including aluminum ions to yield a aluminum-ion-containing porous media, contacting the aluminum-ion containing porous media with a reducing agent to impregnate elemental aluminum in the porous media, and oxidizing the elemental aluminum to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. In some cases, a pH of an aqueous mixture including the aluminum-ion-containing porous media may be adjusted to form a floc including aluminum hydroxide, and the aluminum hydroxide-containing porous media may be contacted with a reducing agent to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. The porous hybrid media may advantageously be prepared at low temperature (e.g., room temperature).

The present disclosure relates to a method and a solid phase microextraction sampling instrument for inserting into or through a solid or semisolid material to extract a component of interest from a sample, comprising a support structure at least partially coated with an extraction phase for extracting the component of interest, a protrusion that shields the coating during insertion, where the distances within a cross-sectional plane of the sampling instrument are greater than or equal to the corresponding distances in all of the cross-sectional planes located between the cross-sectional plane of interest and the insertion end of the sampling instrument. The present disclosure also discusses methods of making the instrument, desorption chambers, and methods for desorbing a component of interest from the instrument.

A chlorine neutralizer which can be used and manufactured in a simplified manner, a throw-in type chlorine neutralizer containing the same, a chlorine neutralizing apparatus, and a chlorine neutralizing method are provided. A chlorine neutralizer which neutralizes a chlorine-based component contains at least one selected from a vinyl alcohol based polymer and a polyamide resin, and the vinyl alcohol based polymer contains at least vinyl alcohol in a repeating structural unit.