A fiber is provided as a substrate for a functional nanostructure (coated fiber), composed of (a) a fiber substrate; (b) a reactive dye conjugating moiety covalently bound to the fiber substrate; (c) a bonding agent covalently bound to the reactive dye conjugating moiety; and (d) the functional nanostructure bound to the bonding agent. A method of making the coated fiber is also provided, involving the following steps in any order: covalently binding the reactive dye conjugating moiety to the fiber; covalently binding a bonding agent to the reactive dye conjugating moiety; and binding the functional nanostructure to the bonding agent. The nanostructures are tenaciously attached to the fibers, resisting very rough treatments, and can be made using inexpensive and widely available reactive dyes under non-stringent synthesis conditions.

A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting essentially of a water soluble polymer, a water soluble copolymer, an alcohol soluble polymer, an alcohol soluble copolymer, and combinations of such polymers, wherein the polymer is chemically bonded to the siliceous substrate by a silane linking material having the general formula
O.sub.3/2SiQY
that is derived from an alkoxy-functional silane having the general formula
(RO).sub.3SiQX
and processes for preparing the crosslinked polymer that is chemically bonded to the surface of the siliceous substrate.

A new strategy to design container molecules is presented. Sulfonylcalix[4]arenes, which are synthetic macrocyclic containers, are used as building blocks that are combined with various metal ions and tricarboxylate ligands to construct metal-organic ‘super-containers’ (MOSCs). These MOSCs possess both endo and exo cavities and thus mimic the structure of viruses. The synthesis of MOSCs is highly modular, robust, and predictable.

An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52 wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO:4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

One embodiment of the present invention is a protein having affinity for an immunoglobulin, which is a protein having two or more domains derived from any of the amino acid sequences of E, D, and A domains of protein A, and in the amino acid sequence of at least one of the domains, one or more lysines are included, and the C-terminal lysine is deleted or substituted, or a protein having affinity for an immunoglobulin, which is a protein having two or more domains derived from any of B, C, and Z domains of protein A, and in the amino acid sequence of at least one of the domains, one or more lysines are included, and lysine at position 4 and the C-terminal lysine are deleted or substituted.

This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.

Chromatography resins having mixed mode ligands and methods of using such resins are provided.

The super absorbent polymer according to the present invention has reduced 3-hour saline solution re-wet while having a high absorption rate and absorption against pulp, and thus can be used for hygienic materials such as diapers, thereby exhibiting excellent performance.

The present invention relates to a multimodal adsorption medium, in particular a multimodal chromatography medium, a method for its production, as well as use of the adsorption medium according to the invention or an adsorption medium produced according to the invention for the purification of biomolecules.

The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.