The present invention relates to a multimodal adsorption medium, in particular a multimodal chromatography medium, a method for its production, as well as use of the adsorption medium according to the invention or an adsorption medium produced according to the invention for the purification of biomolecules.

A process for producing a material that absorbs carbon dioxide from atmospheric air, comprising: using a material that has a core and terminal primary amine end groups; and epoxy end capping of the terminal primary amine end groups to give secondary amine end groups.

Chromatography resins having mixed mode ligands and methods of using such resins are provided.

Provided is a fibrous adsorbing material used for the adsorption and recovery of metals in a solution, which is a fibrous metal-adsorbing material that can be produced using existing production facilities without using special facilities or complicated operations, has high durability, is easy to diversify, and can be processed into various forms. The fibrous metal-adsorbing material is produced by a) a step of preparing an acrylate polymer having a large number of glycidyl groups in the molecule, b) a step of kneading a low-melting-point fiber matrix polymer therewith, c) a step of making the resulting mixture into a fibrous form by an melt-blend spinning method, and d) a step of allowing a long-chain ligand having an amino group or an imino group to react with glycidyl groups on the fiber surface to introduce a metal-adsorbing functional group. The fibrous metal-adsorbing material has high durability, is easy to diversify, and has various forms.

Chromatography resins having mixed mode ligands and methods of using such resins are provided.

A chromatographic composition includes a solid phase substrate and an ionically-modified hydrophilic ligand coupled to the solid phase substrate. The ionically-modified hydrophilic ligand includes a hydrophilic ligand portion covalently bonded to the solid phase substrate with the hydrophilic ligand including a polar group and a plurality of hydroxyl groups. The ionically-modified hydrophilic ligand also includes an ionic group directly or indirectly coupled to the hydrophilic ligand portion. Methods of producing the chromatographic composition are also provided.

The present disclosure pertains to compositions comprising a non-porous particle core coated with a hydrophilic polymer with surface-grafted polyionic chains. In some aspects, the present disclosure pertains to chromatographic separation devices that comprise such compositions. In some further aspects, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such compositions and (b) flowing a mobile phase through the column.

A hydrophobic interaction chromatography (HIC) composition includes a solid phase substrate and a hydrophobic-modified hydrophilic ligand covalently coupled to the solid phase substrate. The hydrophobic-modified ligand includes a hydrophilic ligand portion covalently bonded to the solid phase substrate with the hydrophilic ligand portion including a polar group and a plurality of hydroxyl groups. The hydrophobic-modified ligand also includes a peptide segment covalently coupled to the hydrophilic ligand portion and comprising from two to twenty amino acid residues. The peptide segment is linearly arranged, and each amino acid is the same as or different than the other amino acid residues for promoting HIC interaction.