Chromatography resins having mixed mode ligands and methods of using such resins are provided.

Disclosed herein is a composite material in the form of a bead, the beads are either formed from: a polyethyleneimine, graphene oxide, and zeolite nanoparticles, where the bead has a hollow core and a layered shell structure comprising a plurality of layers of graphene oxide and a plurality of layers of polyethyleneimine, where any two layers of graphene oxide are separated by a layer of polyethyleneimine and the zeolite nanoparticles are intercalated between the plurality of graphene oxide layers, and the polyethyleneimine is crosslinked by a negatively charged crosslinking agent; or a polyethyleneimine and graphene oxide, where the bead has a hollow core and a layered shell structure comprising a plurality of layers of graphene oxide and a plurality of layers of polyethyleneimine, where any two layers of graphene oxide are separated by a layer of polyethyleneimine, and covalent bonds are formed between the polyethyleneimine and the graphene oxide to crosslink the polyethyleneimine to the graphene oxide. Also disclosed herein are methods of using the composite material and its manufacture.

The present invention relates to a method for the separation and purification of glycoforms with an ion exchange separation material with amino-acid based endgroups.

Stationary phase for preparative High Pressure Liquid Chromatography (HPLC) for preparative separation of Rare Earth Elements (REEs), the stationary phase comprising porous particles suitable for HPLC having a non-polar surface being impregnated with ligands binding REEs, wherein the porous particles has a pore size of 300 or higher, is described.

Sorbent polymer composites and a solution-casting method of making hydrophobic sorbent polymer composites for CO.sub.2 adsorption applications are described. The sorbent polymer composites are comprised of a polymer matrix, a dispersed CO.sub.2 sorbent, and an optional filler particle for hydrophobicity modification.

The present disclosure pertains to compositions comprising a non-porous particle core coated with a hydrophilic polymer with surface-grafted polyionic chains. In some aspects, the present disclosure pertains to chromatographic separation devices that comprise such compositions. In some further aspects, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such compositions and (b) flowing a mobile phase through the column.

Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS/cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.

The invention relates to the field of functional materials technology, specifically to a preparation method, product, and application of hydrophobic melamine resin foam. The preparation method of hydrophobic melamine resin foam includes the following steps: Vacuum-impregnate the melamine resin foam with a solution of poly(dimethyl diallyl ammonium chloride). Subsequently, immerse the cationic-coated melamine resin foam in a sodium polyacrylate solution. Next, immerse the anionic-coated melamine resin foam in a titanium dioxide mixed solution for cross-linking. After cross-linking, immerse the melamine resin foam in a solution of tridecafluoro-octyl triethoxysilane. After impregnation, dry the foam to obtain hydrophobic melamine resin foam. The preparation method of the invention is simple, cost-effective, and easy to scale up for industrial applications. The hydrophobic melamine resin foam prepared using this method can achieve a hydrophobic contact angle of up to 150 and exhibits excellent oil absorption performance.

The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.

Described herein are sorbents functionalized with ligands having an aminosilicone functional group. Also described herein are methods of making the sorbents functionalized with ligands having an aminosilicone functional group. Also described herein are methods of using the sorbents functionalized with ligands having an aminosilicone functional group.