Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.

A system may automatically conduct hygiene cycles for a confined space such an interior space of a box suitable for storing and/or carrying packaged food. The system may include a hygiene device that can be attached to the box to conduct the hygiene cycles and a user interface device that can wirelessly communicate with the hygiene device to control the conduction of the hygiene cycles. The system may also automatically collect information related to the hygiene cycles using the hygiene device and transmit the collected information to a network directly or through the user interface device.

Dispenser comprising at least one container and at least one source for biocidal radiation, such as a UV-light source. The at least one container comprises a lid, which is transparent for the biocidal radiation. The source for biocidal radiation is at a distance above the lid, e.g., in the dispenser housing.

An automatic sterilizer system for a trunk includes a goods sensor for sensing an existence of goods or a change amount of a location or height of goods in the trunk; an ultraviolet lamp for irradiating ultraviolet rays to an inside of the trunk; a camera sensor for photographing an image in the inside of the trunk; an air injection unit for injecting air to the inside of the trunk through an air nozzle; a trunk opening/closing sensor for sensing opening/closing of the trunk; and a control unit for sensing the existence or location and height change amounts of goods loaded in the trunk from the goods sensor, and actuating the ultraviolet lamp and the air injection unit according to the sensed existence and change amounts of goods to sterilize the inside of the trunk.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

A system and method for processing pharmaceutical containers includes at least one production facility for filling and closing the containers in at least one processing room and at least one preparation device which is or can be arranged spatially remote from the at least one production facility. At least one transportable container device can be docked to the production facility for introducing pharmaceutical production material which comprises the containers and closure elements. The container device can be docked to the preparation device to receive the production material. A metering device can be docked to the production facility in order to insert a filling needle and a fluid conduit.

A content-filling system (10) includes a water sterilization line (50) that sterilizes water, an undiluted-solution sterilization line (70) that sterilizes a product undiluted solution, a water-filling device (21) that is connected to the water sterilization line (50) and is disposed in a first sterile chamber (70f), an undiluted-solution-filling device (22) that is connected to the undiluted-solution sterilization line (70) and is disposed in a second sterile chamber (70h), and a control unit (90) that controls the water-filling device (21) and the undiluted-solution-filling device (22). The control unit (90) causes the inside of the second sterile chamber (70h) to be cleaned with the inside of the first sterile chamber (70f) kept sterile. The control unit (90) causes the inside of the second sterile chamber (70h) to be sterilized with the inside of the first sterile chamber (70f) kept sterile.

A sterile filling method for an additive product container defining a product chamber adapted for containing an additive product can include forcing a first gas at a first temperature into the product chamber over a first threshold period to heat the product chamber to a first threshold temperature, such as to sterilize the product chamber. The sterile filling method can further include dispensing the additive product at a second temperature into the product chamber, sealing the product chamber; and, rotating the additive product container from a first position to a second position, such as to bring the additive product into contact with a sealing member sealing the product chamber.

A filter cartridge for a sterilizing cabinet includes a first gasket comprising a rigid or flexible edge portion and forming a frame defining a hollow center portion, a first filter comprising a porous material for maintaining a sterilized condition in the sterilizing cabinet and passing gaseous materials through the porous material, wherein the first filter is affixed to the first gasket, and a second filter comprising a porous material for maintaining a sterilized condition in the sterilizing cabinet and passing gaseous materials through the porous material, wherein the second filter is either affixed to the first filter or the first gasket opposite the first filter, and wherein the filter cartridge provides sufficient structural integrity to form a sealing interface with a confronting surface of the sterilizing cabinet.

A ready-to-use, gamma-ray sterilized, surgical antiseptic composition comprising an initial non-toxic concentration of povidone-iodine above a minimum effective concentration of available iodine, iodide in sufficient quantity to provide donor iodine upon gamma irradiation to stabilize said povidone-iodine and maintain said minimum effective concentration of available iodine, and a buffered saline solution.