The invention relates to a mutation in the Dock8 encoding gene that is causative for type 1 diabetes mellitus at least in the rat (rattus norvegicus) or mouse, the rat or mouse preferably having an MHC predisposing towards type 1 diabetes mellitus and/or a mutation in the von Willebrand factor Vwa2. Embodiments of the invention comprise a process for generating a non-human mammal by genetic manipulation to contain at least heterozygously, preferably homozygously, the mutation causative for type 1 diabetes mellitus, preferably in combination with an MHC predisposing for type 1 diabetes mellitus and/or with a mutation in the von Willebrand factor Vwa2.

A pressure distribution element holding a ring, attachable to the horizontal chest strap of a chest harness which is closable-openable by a hook-and-loop fastener, by connecting the chest strap loop section and the chest strap hook section comprising a chest strap connecting portion, and a vertical connecting element connecting the horizontal chest strap of the dog harness to the belly strap, forming a loop around the belly strap by folding back on itself, comprising at least a loop section, continued in a lower loop portion resting on the belly strap of the dog harness.

A container of pet food and an apparatus for preparing the pet food are disclosed. The apparatus includes a scanner for reading a pet food identifier on the container. The scanner is adapted to read the pet food identifier and provide it to a controller. The controller is adapted to obtain food preparation parameters from an external database and to cause the apparatus to then prepare the pet food according thereto. The containers has an identically-shaped periphery and the apparatus is adapted to receive that periphery such that each container is properly positioned regardless of the container's volume.

The present invention relates to the field of biotechnology, in particular to application of a GPR45 gene. The present invention discloses, for the first time, a correlation between GPR45 and obesity and also discloses that obesity may be caused if the GPR45 gene is knocked out or the expression of the GPR45 gene is reduced. Moreover, an obese mouse model is established by adopting a method of blocking the expression of the GPR45 gene for the first time, which is more similar to the mechanism underlying the obesity of human, is thus an ideal model for obesity basis and clinical application researches and can be well applied in screening of drugs for treating obesity.

A pressure distribution element holding a ring, attachable to the horizontal chest strap of a chest harness which is closable-openable by a hook-and-loop fastener, by connecting the chest strap loop section and the chest strap hook section comprising a chest strap connecting portion, and a vertical connecting element connecting the horizontal chest strap of the dog harness to the belly strap, forming a loop around the belly strap by folding back on itself, comprising at least a loop section, continued in a lower loop portion resting on the belly strap of the dog harness.

In one aspect, the disclosure provides cells and transgenic non-human mammals for the production of Fc fragments, as well as compositions and uses thereof.

The invention comprises equine leggings, harness, and one-piece, stretch fabric, zippered bodysuit oras a variantlightweight, long-tassel fringe bodysuit with modified harness. Combined, the invention provides complete equine body protection from flying and biting insects. The leggings stretch from hoof to shoulder; the harness encircles the neck then extends down the horse's spine from wither to rump; suspender-type straps extend from the harness to secure the leggings, which feature elasticized gussets at top and bottom to aid fitting; the bodysuit, with a singular, contoured zippered fastening under the belly, stretches around and over first the head, along the horse's body and back, then over the tail in one fitting. The long-tassel fringe bodysuit variant attaches to a modified harness that omits the suspender straps and adds a loop to encircle the tail. The horse can be ridden under saddle while wearing bodysuit, harness, and leggings.

The present invention relates to expression cassette and vector comprising Alzheimer's disease-related genes and a cell line transformed by means of same, and more specifically, the expression cassette according to the present invention comprises amyloid precursor protein (APP), Tau protein, and presenilin-1 (PS1) genes associated with Alzheimer's disease so that mutant genes thereof can be simultaneously expressed. Additionally, the present invention relates to a cell line transformed by means of the expression cassette or vector comprising said genes, and further, to an animal model transformed by means of the vector or cell line.

A display apparatus includes a transparent electronic display such as a non-backlit LCD screen, a display area disposed behind the transparent electronic display, and a light source for illuminating the display area. When the light source is activated, the pixels of the LCD screen, and objects behind the screen, become visible. Various examples of the display apparatus include additional enhancements to the visual image and/or functionality. These enhancements include additional monitors for coordinated displays, user-controlled turntables with coordinated informational displays, parallax compensation, RFID sensors for identifying objects to be displayed, and switchable liquid crystal films and/or polarized mirror coatings to further control revealing and concealing of objects behind the screen. Some examples of the display apparatus may include an animal habitat. The animal habitat may be selectively revealed or concealed. The display apparatus may incorporate screen displays with animal movements for unique visual effects.

A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring.