An object of the present invention is to provide a ligand-immobilized sea-island composite fiber in which generation of fine particles due to peeling of a sea component from an island component and generation of fine particles due to destruction of a fragile sea component are both suppressed. The present invention provides a sea-island composite fiber comprising a sea component and island components, in which a value (L/S) obtained by dividing the average total length (L) of the perimeter of all island components in a cross section perpendicular to the fiber axis by the average cross-sectional area (S) of the cross section is from 1.0 to 50.0 μm.sup.−1, a distance from the surface to the outermost island component is 1.9 μm or less, and an amino group-containing compound is covalently bonded to a polymer constituting the sea component at a charge density of 0.1 μmol or more and less than 500 μmol per 1 gram dry weight.

In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such core-shell particles and (b) flowing a mobile phase through the column.

The present disclosure relates to water-absorbent resin particles in which a contact angle of 0.9% by mass saline at 25° C.±2° C. is 100 degrees or larger, and an absorbent material containing the water-absorbent resin particles.

A trivalent doped cerium oxide composition is beneficial to aid in the removal of biological contaminants, such as bacteria, viruses, fungi, protozoa (e.g., amoebae), yeast and algae. These trivalent doped cerium oxide compositions can be used to remove these biological contaminants from fluids, including air and water, and from solid surfaces. The compositions also include a support material. Also described are methods of using compositions containing these trivalent doped cerium oxide compositions to remove biological contaminants.

The present invention relates to a lectin-macromolecular carrier coupling complex for separating glycosylated exosomes from a clinical sample, which comprises a macromolecular carrier and lectins coupled to the outer side of the macromolecular carrier. The complex may simply, conveniently, rapidly, and accurately separate glycosylated exosomes from a clinical sample with a high separation efficiency and a good repeatability; and the separated exosomes are intact in morphology without rupturing or cracking, may be directly used for liquid detection of glycosylated exosomes, or directly used for immunology-related detection, or directly used for gene detection or analysis after extracting related nucleic acids from the exosomes.

Provided herein are methods of making an adsorbent bed useful as a micro-reactor, or a catalytic and/or separation device. The adsorbent bed comprises a metal-organic framework composite. In the present methods, one or more metal-organic frameworks in powder form are mixed in a liquid to produce a metal-organic framework suspension or other type of metal-organic framework coating. A monolith is coated with the suspension or coating to provide the metal-organic framework composite having at least one metal-organic framework coating layer deposited on and bounded to the monolith. The metal-organic framework composite produced has a BET surface area of about 1 m.sup.2/g to about 300 m.sup.2/g and/or a comparative BET surface area of about 40% to about 100% relative to the metal-organic framework monolith, and pore size between about 1 nm and about 50 nm.

Methods of preparing polymer-filled chromatography resin and their uses are provided.

A method for preparing, in the internal volume of at least one channel, a monolithic support on which uranyl cations are immobilised. The method comprises: (a) activating the inner surface of the channel(s); (b) introducing, into the internal volume of the channel(s), a polymerisation solution comprising: a monomer comprising a phosphate group, at least one crosslinking agent, several solvents, and a radical polymerisation initiator; (c) polymerising the polymerisation solution; (d) rinsing the monolithic support obtained in step (c); and (e) contacting the monolithic support previously rinsed, with a solution comprising uranyl cations. A method for capturing proteins that selectively bind uranium by means of a monolithic support prepared by the above-mentioned method, as well as to a method for recovering proteins that selectively bind uranium with the capture method.

Provided is a separation method for amine, the separation method including performing liquid chromatography, wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on a carrier is used as a stationary phase, and wherein a mobile phase contains an aqueous solution of at least one salt of a hydrophobic anion selected from the group consisting of a salt of a chaotropic anion and a salt of a hydrophobic organic acid.

The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.