The invention relates to a method for preparing a monolithic stationary phase in the interior volume of a chromatography column made of thermoplastic polymer. This method comprises the following steps: (i) modifying the inner wall of the chromatography column by implementing the following steps: (a) preparing a polymerizable anchoring composition comprising at least one particular methacrylate monomer, one or more solvents and 2,2-dimethoxy-2-phenylacetophenone, (b) depositing, on the inner wall of the column, the polymerizable anchoring composition prepared in step (a), and (c) polymerizing the polymerizable anchoring composition by irradiation with ultraviolet radiation; (ii) introducing, into the interior volume of the column, a polymerizable monolith synthesis composition comprising first and second particular (meth)acrylate monomers, one or more pore-forming agents and a free-radical polymerization initiator; and (iii) polymerizing the polymerizable monolith synthesis composition. The invention also relates to a method for producing a chromatography column comprising such a monolithic stationary phase and to a chromatographic separation method using such a column.

A composite material of polyurethane foam having a layer of reduced graphene oxide and polystyrene is described. This composite material may be made by contacting a polyurethane foam with a suspension of reduced graphene oxide, drying, and then irradiating in the presence of styrene vapor. The composite material has a hydrophobic surface that may be exploited for separating a nonpolar phase, such as oil, from an aqueous solution.

Provided are sequestering agents for sequestering non-water moieties from an aqueous solution. The sequestering agents may comprise a detergent; and a polymer operable to stabilize formation of a detergent micelle thereby causing the detergent and polymer to self-assemble into a nanonet upon exposure to the aqueous solution. Also provided are kits therefore and methods for use of the sequestering agents and kits.

Polymer sorbents selectively remove cytokines and bacterial endotoxins from whole blood and other body liquids, in particular blood plasma, lymph etc., as well as from aqueous protein solutions and aqueous organic compound solutions, also containing inorganic salts. The sorbent is able to remove both cytokines and bacterial endotoxins, improve selectivity of the polymer sorbents in respect to the compounds as well as provide a simple and effective method of producing said sorbent.

In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 Å to 3000 Å. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such organic polymer core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such organic polymer core-shell particles and (b) flowing a mobile phase through the column.

A cationic composite filter aid may include a silicate substrate, a silica precipitated on the silicate substrate, and a cationic surface modification of the precipitated silica. A method for making a cationic composite filter aid may include providing a silicate substrate, precipitating a silica onto the silicate substrate to form a composite filter aid, and cationically modifying the precipitated silica to form a cationic composite filter aid. A method for filtering a liquid may include providing a liquid for filtering and filtering the liquid through a cationically modified composite filter aid. The cationically modified composite filter aid may include a silicate substrate, a precipitated silica, and a cationic surface modification of the precipitated silica.

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

A column for removal of a component from a fluid is disclosed. The column has a compartment with a cross sectional area. The compartment contains beads having a diameter. A ligand selected to bind to the component is coupled to the beads. The cross-sectional area and bead diameter are selected to maintain a flow velocity of the fluid within the compartment below a first threshold, thereby reducing leaching of the ligand into the fluid. Also described herein is an adsorbent comprising a ligand that is attached to a substrate by an amine bond, wherein the ligand is resistant to dissociation from the substrate.

A composite material of polyurethane foam having a layer of reduced graphene oxide and polystyrene is described. This composite material may be made by contacting a polyurethane foam with a suspension of reduced graphene oxide, drying, and then irradiating in the presence of styrene vapor. The composite material has a hydrophobic surface that may be exploited for separating a nonpolar phase, such as oil, from an aqueous solution.

The present invention provides a separation material that comprises porous polymer particles comprising a styrene-based monomer as a monomer unit; and a coating layer comprising a macromolecule having hydroxyl groups, which covers at least a portion of the surface of the porous polymer particles, and the separation material has a 5% compressive deformation modulus of 100 to 1,000 MPa, and has a mode diameter in the pore size distribution of 0.1 to 0.5 μm.