Chromatography resins having mixed mode ligands and methods of using such resins are provided.

The invention describes a method to regenerate the carbon capture capacity of amino based sorbents used for carbon capture, after they have lost partially or totally their carbon dioxide capture capacity due to oxidation during said carbon capture process.

A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic charge repulsion.

Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.

Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)N(R.sup.1, R.sup.2)R.sup.3-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; R.sup.1 and R.sup.2 are each selected from hydrogen and an alkyl comprising 1-6 carbons; R.sup.3 is an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR.sup.4, O, or S; wherein R.sup.4 is hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.

The present invention relates to the use for affinity purification of an antibody or a fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material.

Modified carbon-based sorbents configured for improved carbon capture, methods for increasing CO.sub.2 capture potential of modified carbon-based sorbents, and methods for improving noncovalent interactions of modified carbon-based sorbents with CO.sub.2, N.sub.2, and H.sub.2 are disclosed herein. The modified carbon-based sorbents have porous carbon surfaces and/or mesoporous carbon surfaces comprising one or more in-plane sites having at least one first nitrogen functionality and one or more out-of-plane sites having at least one second nitrogen functionality, wherein the at least one first nitrogen functionality is a different nitrogen functionality than the at least one second nitrogen functionality. The methods comprise contacting the modified carbon-based sorbents to gaseous streams containing CO.sub.2.

A process for extracting a surfactant from a mixture using a boronic acid modified material.

Disclosed herein are embodiments of compounds, conjugates, and devices, such as columns comprising such compounds and/or conjugates, that can be used to identify, separate, and quantify post-translationally modified analytes. The disclosed compounds and conjugates can be used to discriminate between analytes, such as peptides, having different post-translation modifications, such as methylations, phosphorylations, acetylations, citrullinations, hydroxylations, nitrosylations, ADP-ribosylations, glycosylations, propionylations, butyrylations, crotonylations, 2-hydroxyisobutyrylations, malonylations, succinylations, formylations, ubiquitinations, neddylations, proline cis-trans isomerizations. In particular disclosed embodiments, the compounds and conjugates can be used to separate peptides having different degrees of methylation.

A Product is described and which contains at least one type of ligand bound to a separation material and which allows selective binding or cleavage of a biomolecule for example in human blood.