A stationary phase for high-performance liquid chromatography including monofunctional primary silane functionalized silica provides improved separation performance for the preparative or process scale purification of cannabidiol (CBD) and tetrahydro-cannabinol (THC). Silica bonded with monofunctional primary silane(s) provides more efficient separation of these molecules through higher resolution values, reduced peak broadening and lower separation impedance, thus enabling higher purity product or more efficient purification process.

The present specification relates to compositions, devices, apparatus, methods, kits and systems for sample preparation (e.g., separation, reduction or removal of small molecules from biomolecules in a sample). Exemplary small molecules that can be separated, reduced or removed have a molecular weight range of <2000 Da. and may include, but are not limited to, dyes, biotin, affinity tags, crosslinkers, reducing agents, labels, nanoparticles, radioactive ligands, mass tags, unreacted molecules and combinations, intermediates and derivatives of the foregoing. Exemplary biomolecules present in a sample, include but are not limited to, proteins, glycoproteins, antibodies, peptides, nucleic acids, polysaccharides, carbohydrates and lipids. Methods, compositions, kits, devices, apparatus and systems of the disclosure may advantageously provide superior separation of small molecule contaminants and additionally reduce time and expenses related to separation of small molecules from larger biomolecules in samples. Biomolecules separated as set forth herein are amenable to better downstream processing.

The present application provides a composite material that comprises a solid and solid-supported non-polymeric switchable moiety, wherein the switchable moiety comprises a functional group that is switchable between a first form and a second form, said first form being neutral and hydrophobic, and said second form being ionized and hydrophilic. The composite material converts to, or is maintained in, said second form when the switchable moiety is exposed to CO.sub.2 at amounts sufficient to maintain the ionized form. The composite material converts to, or is maintained in, said first form when CO.sub.2 is removed or reduced to an amount insufficient to maintain the ionized form. CO.sub.2 is removed or reduced by exposing the composite material to heat and/or a flushing inert gas such as N.sub.2, Ar, or air. Envisioned uses of these composite materials includes removing water from non-aqueous solvents, removing water vapor from gaseous mixtures, and cleaning industrial reaction vessels and/or pipelines.

The present invention provides a novel, simple and reliable method for the separation of carbohydrate tautomers. The method comprises steps of chromatographically separating a sample using a chromatographic device. The method can be used to separate mono- and disaccharides tautomeric species including arabinose, xylose, fructose, mannose, galactose, glucose, lactose, and maltose.

A method for solid-phase extraction is disclosed. The method includes fabricating a solid-phase extraction medium by incorporating a plurality of modified mesoporous silica particles within pores of a cotton fabric matrix, putting the solid-phase extraction medium in contact with a fluid containing metal ions including one of immersing the solid-phase extraction medium in the fluid containing metal ions or passing the fluid containing metal ions through the solid-phase extraction medium by continuously circulating the fluid through the solid-phase extraction medium, and extracting the metal ions from the fluid by adsorbing the metal ions onto the solid-phase extraction medium responsive to a contact between the solid-phase extraction medium and the fluid containing metal ions.

An organic material which includes a solid polymer substrate onto which molecules having the following general formula (I) are grafted:

##STR00001##

The invention also relates to the use of the organic material to extract the uranium (VI) from an aqueous acid solution, to associated methods for extracting and retrieving uranium (VI) as well as to a molecule which is a precursor of the organic material. The disclosure also relates to the use of the organic material to extract the uranium (VI) from an aqueous acid solution, to associated methods for extracting and retrieving uranium (VI) as well as to a molecule which is a precursor of the organic material.

The invention relates to an organic-inorganic hybrid material which comprises an inorganic solid support on which are grafted organic molecules of the general formula (I) hereafter: ##STR00001##
and relates to methods allowing preparation of this hybrid material as well as to the uses of the hybrid material for extracting uranium(VI) from an aqueous medium comprising phosphoric acid.

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.

An adsorbent for rare earth element and a method for recovering a rare earth element, in which a rare earth element contained in an aqueous solution can be simply and inexpensively adsorbed and recovered, and a rare earth element present in an aqueous solution in combination with a base metal can be selectively adsorbed and recovered. The adsorbent includes a base material and diglycolamic acid introduced into the base material. The method for recovering a rare earth element includes steps of: bringing an aqueous solution containing a rare earth element into contact with the adsorbent for rare earth element to allow the rare earth element to be adsorbed on the adsorbent for rare earth element; and desorbing the rare earth element adsorbed on the adsorbent for rare earth element with an acid of 1 N or less.

The invention relates to the use of an organic-inorganic hybrid material, comprising an inorganic solid support on which are grafted organic molecules having the general formula (I) below: ##STR00001##
in which: x, y and z=0 or 1, with at least one of x, y and z different from 0; m=1 to 6; v and w=0 or 1, with v=1 when w=0, and v=0 when w=1; if x=0, R.sup.1H or a saturated or unsaturated, linear or branched, C.sub.1 to C.sub.12 hydrocarbon group, whereas, if x=1, R.sup.1=a group bound to the inorganic solid support by at least one covalent bond; if y=0, R.sup.2H or a saturated or unsaturated, linear or branched, C.sub.1 to C.sub.12 hydrocarbon group, whereas, if y=1, R.sup.2=a group bound to the inorganic solid support by at least one covalent bond; if z=0, R.sup.3H or a saturated or unsaturated, linear or branched, C.sub.1 to C.sub.12 hydrocarbon group, whereas, if z=1, R.sup.3=a group bound to the inorganic solid support by at least one covalent bond; R.sup.4 and R.sup.5H, a saturated or unsaturated, linear or branched, C.sub.2 to C.sub.8 hydrocarbon group, or a monocyclic aromatic group;
for extracting uranium(VI) from a sulfuric acid aqueous solution. The invention also relates to a method that makes it possible to recover the uranium(VI) present in a sulfuric acid aqueous solution, selectively with respect to the other metal cations that may also be present in said solution.