The present disclosure relates, in part, to enhanced weathering systems and/or apparatuses and methods of use thereof. In one aspect, the present disclosure provides a method of at least partially sequestering CO.sub.2 from an influent aqueous solution comprising aqueous and/or gaseous CO.sub.2. In another aspect, the present disclosure provides a method of at least partially sequestering CO.sub.2 from a gaseous CO.sub.2 source. In another aspect, the present disclosure provides systems and/or apparatuses suitable for use in the methods described herein. In another aspect, the present disclosure provides a method of optimizing the design and operation of a system for at least partial sequestration of CO.sub.2 from a water source.