Re(V) alkylidyne-based catalytic systems for alkyne metathesis reactions capable of effecting alkyne metathesis, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, at room temperature to moderate temperatures. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates and can be readily prepared on a large scale, and thus are practical catalytic systems of Re(V) alkylidynes.

Re(V) alkylidyne-based catalytic systems for alkyne metathesis reactions capable of effecting alkyne metathesis, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, at room temperature to moderate temperatures. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates and can be readily prepared on a large scale, and thus are practical catalytic systems of Re(V) alkylidynes.

Provided is a method that is for producing an alcohol from an olefin compound with an improved selectivity and that enables a catalyst to be easily reused. This method for producing an alcohol comprises: reacting an olefin compound, carbon monoxide, and hydrogen molecules, using a group-9 transition metal complex as a catalyst, in an organic solvent containing at least 30 mol % of an amine compound having at least two nitrogen atoms that form a tertiary amine.

Provided is a method that is for producing an alcohol from an olefin compound with an improved selectivity and that enables a catalyst to be easily reused. This method for producing an alcohol comprises: reacting an olefin compound, carbon monoxide, and hydrogen molecules, using a group-9 transition metal complex as a catalyst, in an organic solvent containing at least 30 mol % of an amine compound having at least two nitrogen atoms that form a tertiary amine.

The invention relates to terpene-derived compounds, such as acids, esters thereof, produced by ozonolysis of terpenes, and to alcohols, amides, nitriles derived therefrom, as well as to processes for synthesizing them. Specifically, 2,3,7-trimethyloct-6-en-2-ol, 2,3,7-trimethyloct-7-en-2-ol, or a mixture thereof, produced by Grignard reaction of a terpene derived carboxylate with methyl magnesium bromide is disclosed.

The invention relates to terpene-derived compounds, such as acids, esters thereof, produced by ozonolysis of terpenes, and to alcohols, amides, nitriles derived therefrom, as well as to processes for synthesizing them. Specifically, 2,3,7-trimethyloct-6-en-2-ol, 2,3,7-trimethyloct-7-en-2-ol, or a mixture thereof, produced by Grignard reaction of a terpene derived carboxylate with methyl magnesium bromide is disclosed.

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a -amino--biphenyl--methylalkanoic acid, or acid ester, backbone.

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a -amino--biphenyl--methylalkanoic acid, or acid ester, backbone.

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a -amino--biphenyl--methylalkanoic acid, or acid ester, backbone.

Methods for the preparation of alkenes including insect pheromones are described. The methods include homologation reactions employing reagents such as 1,3-diesters, epoxides, cyanoacetates, and cyanide salts for elongation of starting materials and intermediates by one or two carbon atoms. The alkenes include insect pheromones useful in a number of agricultural applications.