Disclosed herein are methods for the recovery of target bio-based products using a sorption-based technology with a mixed elution solvent optimized for minimized downstream distillation energy input.

The invention relates to a process for preparing carboxylic acids or salts thereof by hydrolysis or saponification of an ester, which is obtained by alkoxycarbonylation of a C2 to C20 hydrocarbon having at least one multiple bond, preferably having at least one olefinic double bond, in which the homogeneous catalyst system used is separated from the product mixture by means of membrane separation. In a development of the present invention, the ester thus formed is converted into another ester by transesterification and then hydrolyzed or saponified.

The invention relates to a process for preparing carboxylic acids or salts thereof by hydrolysis or saponification of an ester, which is obtained by alkoxycarbonylation of a C2 to C20 hydrocarbon having at least one multiple bond, preferably having at least one olefinic double bond, in which the homogeneous catalyst system used is separated from the product mixture by means of membrane separation. In a development of the present invention, the ester thus formed is converted into another ester by transesterification and then hydrolyzed or saponified.

A process for preparing a ketone or carboxylic acid by catalytic oxidation of a secondary or primary alcohol comprises adding the secondary or primary alcohol as a raw material and N-hydroxyphthalimide (NHPI) combined with phthalocyanine, serving as a catalytic system, into an amount of an organic solvent into which oxygen gas is then introduced, to proceed with an oxidation reaction to give the ketone or carboxylic acid. The oxygen gas is employed as the source of an oxidant. The oxidation reaction may be carried out under normal pressure at 60 to 120 C. for 9 to 36 hours. The process can produce a high yield of ketone or carboxylic acid. Compared with conventional technology, the process has several advantages, such as the green oxidant, the cheap catalyst which can also be easily prepared and separated, and mild reaction conditions, and it is also an environmentally friendly process for alcohol oxidation.

A process for preparing a ketone or carboxylic acid by catalytic oxidation of a secondary or primary alcohol comprises adding the secondary or primary alcohol as a raw material and N-hydroxyphthalimide (NHPI) combined with phthalocyanine, serving as a catalytic system, into an amount of an organic solvent into which oxygen gas is then introduced, to proceed with an oxidation reaction to give the ketone or carboxylic acid. The oxygen gas is employed as the source of an oxidant. The oxidation reaction may be carried out under normal pressure at 60 to 120 C. for 9 to 36 hours. The process can produce a high yield of ketone or carboxylic acid. Compared with conventional technology, the process has several advantages, such as the green oxidant, the cheap catalyst which can also be easily prepared and separated, and mild reaction conditions, and it is also an environmentally friendly process for alcohol oxidation.

An integrated process for the preparation of carboxylic acids using iso-paraffins is provided. The process includes oxidatively carbonylating a compound having a carbon-hydrogen bond with dialkyl peroxide, carbon monoxide and water. Concurrently, the iso-paraffin is converted to iso-alcohol. The process provides access to a wide range of useful carboxylic acids and operates under relatively mild conditions.

An integrated process for the preparation of carboxylic acids using iso-paraffins is provided. The process includes oxidatively carbonylating a compound having a carbon-hydrogen bond with dialkyl peroxide, carbon monoxide and water. Concurrently, the iso-paraffin is converted to iso-alcohol. The process provides access to a wide range of useful carboxylic acids and operates under relatively mild conditions.

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to binary phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to binary phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.

This disclosure provides scalable methods of synthesizing highly pure substituted carboxylic acids. One or more embodiments of the present disclosure relate to methods of synthesizing 2,2-dimethylbutanoic acid.