The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

A bischloroformate composition is represented by a formula (1) below, contains a plurality of Ar components, and has an average number of monomer units (m1), which is calculated by an expression (Numerical Expression 1) below, ranging from 1.0 to 1.99. The plurality of Ar components are each independently Ar.sub.1 or Ar.sub.2. The plurality of Ar components include at least one Ar.sub.1 and at least one Ar.sub.2. Ar.sub.1 is a group represented by a formula (2) below. Ar.sub.2 is a group represented by a formula (3) below. A molar composition ratio represented by Ar.sub.1/(Ar.sub.1+Ar.sub.2) ranges from 45 mol % to 99 mol %. ##STR00001## average number of monomer units (m1)=1+(Mav−M1)/M2 (Numerical Expression 1)

A bischloroformate composition is represented by a formula (1) below, contains a plurality of Ar components, and has an average number of monomer units (m1), which is calculated by an expression (Numerical Expression 1) below, ranging from 1.0 to 1.99. The plurality of Ar components are each independently Ar.sub.1 or Ar.sub.2. The plurality of Ar components include at least one Ar.sub.1 and at least one Ar.sub.2. Ar.sub.1 is a group represented by a formula (2) below. Ar.sub.2 is a group represented by a formula (3) below. A molar composition ratio represented by Ar.sub.1/(Ar.sub.1+Ar.sub.2) ranges from 45 mol % to 99 mol %. ##STR00001## average number of monomer units (m1)=1+(Mav−M1)/M2 (Numerical Expression 1)

The present invention relates to a process for providing carbonic acid esters of formula (I). Further, the invention relates to the intermediates of the formula (IVa).

##STR00001##

The present invention relates to a process for providing carbonic acid esters of formula (I). Further, the invention relates to the intermediates of the formula (IVa).

##STR00001##

The present invention relates to a process for providing carbonic acid esters of formula (I). Further, the invention relates to the intermediates of the formula (IVa).

##STR00001##

The present disclosure relates to spirobiindane derivatives and a process for preparation of the same. Spirobiindane derivatives are used as intermediates for many commercially important compounds such as chiral polymers. The present disclosure provides a simple and economical process for the preparation of spirobiindane derivatives of Formula (I) with high yield and having high purity.

##STR00001##

The present disclosure relates to spirobiindane derivatives and a process for preparation of the same. Spirobiindane derivatives are used as intermediates for many commercially important compounds such as chiral polymers. The present disclosure provides a simple and economical process for the preparation of spirobiindane derivatives of Formula (I) with high yield and having high purity.

##STR00001##