A hydrogen-bonded organic framework nanosheet, a preparation method and application thereof are provided. The preparation method includes in a small heat-resistant glass container, mixing 1,2,4,5-tetrakis (4-carboxyphenyl) benzene (H.sub.4TCPB) with N,N-dimethylformamide (DMF), heating until the solid is dissolved, placing the uncapped small glass container in a large heat-resistant glass container filled with some water, sealing the large glass container, standing and heating the large glass container in a constant-temperature oven to obtain colorless crystals, suction filtering to obtain a solid material, drying, grinding, and then dispersing the solid material in a solvent, performing ultrasonication in an ice-water bath, centrifuging to discard supernatant, and drying to obtain the hydrogen-bonded organic framework nanosheets.

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The present invention relates to an improved process for the preparation of Gabapentin. The process also relates to a new process for the preparation of 1, 1-cyclohexane diaceitic acid monoamide (CDMA), which is a key intermediate for the preparation of Gabapentin.

The present invention relates to an improved process for the preparation of Gabapentin. The process also relates to a new process for the preparation of 1, 1-cyclohexane diaceitic acid monoamide (CDMA), which is a key intermediate for the preparation of Gabapentin.

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

##STR00001##

To provide a compound highly active against pests, a pesticide using the compound, and a method for controlling pests by applying the compound. A phenoxyalkylbenzamide compound represented by the formula (I) or its salt; a pesticide containing it as an active ingredient, and a controlling method, which comprises applying an effective amount of the compound: ##STR00001##
wherein R.sup.1, Y and R.sup.3 are a hydrogen atom or the like, and Ar is as follows: ##STR00002##
wherein R.sup.4 and R.sup.7 are halogen or the like, R.sup.5 and R.sup.6 are a hydrogen atom or the like, m is from 0 to 5, and n is from 0 to 3.

To provide a compound highly active against pests, a pesticide using the compound, and a method for controlling pests by applying the compound. A phenoxyalkylbenzamide compound represented by the formula (I) or its salt; a pesticide containing it as an active ingredient, and a controlling method, which comprises applying an effective amount of the compound: ##STR00001##
wherein R.sup.1, Y and R.sup.3 are a hydrogen atom or the like, and Ar is as follows: ##STR00002##
wherein R.sup.4 and R.sup.7 are halogen or the like, R.sup.5 and R.sup.6 are a hydrogen atom or the like, m is from 0 to 5, and n is from 0 to 3.

The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.