Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

It is described the use of a compound according to formula (I)

##STR00001##

as precursor in perfumery for generating a ketone or aldehyde of formula (II)

##STR00002##

It is described the use of a compound according to formula (I)

##STR00001##

as precursor in perfumery for generating a ketone or aldehyde of formula (II)

##STR00002##

The present invention provides a rubber composition and a tire, which provides superior wear resistance and processability while maintaining the wet performance. The present invention provides a rubber composition for a tire including a rubber component including a modified diene rubber with carboxy group modification, silica and a predetermined polysiloxane; wherein the content of the silica is from 60 to 200 parts by mass per 100 parts by mass of the rubber component, the content of the polysiloxane is from 1 to 20 mass % based on the content of the silica, and the content of the modified diene rubber is from 10 to 100 parts by mass per 100 parts by mass of the rubber component. The present invention also provides a tire using the rubber composition.

The present invention provides a rubber composition and a tire, which provides superior wear resistance and processability while maintaining the wet performance. The present invention provides a rubber composition for a tire including a rubber component including a modified diene rubber with carboxy group modification, silica and a predetermined polysiloxane; wherein the content of the silica is from 60 to 200 parts by mass per 100 parts by mass of the rubber component, the content of the polysiloxane is from 1 to 20 mass % based on the content of the silica, and the content of the modified diene rubber is from 10 to 100 parts by mass per 100 parts by mass of the rubber component. The present invention also provides a tire using the rubber composition.

The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof. ##STR00001## The compounds have multiple mechanisms or functions, for example, inhibition of monoamine oxidase and cholinesterase, scavenging of free radicals, and protection of cells such as nerve cells. The compounds can be used for manufacture of medicaments of cell protection, for prevention and/or treatment of monoamine oxidase, cholinesterase and free radicals related diseases, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and stroke, and free-radical related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof. ##STR00001## The compounds have multiple mechanisms or functions, for example, inhibition of monoamine oxidase and cholinesterase, scavenging of free radicals, and protection of cells such as nerve cells. The compounds can be used for manufacture of medicaments of cell protection, for prevention and/or treatment of monoamine oxidase, cholinesterase and free radicals related diseases, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and stroke, and free-radical related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

The present invention is to provide a compound that can provide a modified polymer exhibiting excellent rigidity, wear resistance, and low heat build-up when used in a rubber composition; a modified polymer obtained by subjecting a polymer to modification with the compound; a rubber composition including the modified polymer; and a tire and a conveyor belt that are produced by using the rubber composition. The compound of the present invention is represented by Formula (M) below. ##STR00001##

The present invention is to provide a compound that can provide a modified polymer exhibiting excellent rigidity, wear resistance, and low heat build-up when used in a rubber composition; a modified polymer obtained by subjecting a polymer to modification with the compound; a rubber composition including the modified polymer; and a tire and a conveyor belt that are produced by using the rubber composition. The compound of the present invention is represented by Formula (M) below. ##STR00001##

The present invention is to provide a compound that can provide a modified polymer exhibiting excellent rigidity, wear resistance, and low heat build-up when used in a rubber composition; a modified polymer obtained by subjecting a polymer to modification with the compound; a rubber composition including the modified polymer; and a tire and a conveyor belt that are produced by using the rubber composition. The compound of the present invention is represented by

##STR00001##

(M) below.