C07D229/02

ARYL ETHER DIAZIRINES FOR USE IN POLYMER CROSSLINKING AND ADHESION

A family of novel diazirine-based molecules is disclosed, as well as methods of manufacture and uses thereof. These compounds allow non-functionalized polymers, such as polyolefins, to crosslink via CH insertion. Such a CH insertion process is useful, for example, for the covalent adhesive bonding of low surface energy films or materials, or for creating rigid 3-dimenional polymeric structures by in-situ doping and activation of the crosslinker. The disclosed crosslinkers can be activated thermally, by UV radiation or by an electric potential.

Diazirine compounds and compositions derived therefrom

A method for forming a film for the fabrication of a microelectronic or optoelectronic device comprising a series of diazirine compounds of formula (I) having utility as photocrosslinkers are disclosed. ##STR00001##
Where, A, L, z, Ar.sub.x and R.sub.y are as defined herein.

Diazirine compounds and compositions derived therefrom

A method for forming a film for the fabrication of a microelectronic or optoelectronic device comprising a series of diazirine compounds of formula (I) having utility as photocrosslinkers are disclosed. ##STR00001##
Where, A, L, z, Ar.sub.x and R.sub.y are as defined herein.

NOVEL COMPOUND FOR LIGHT EMITTING DEVICE AND ORGANIC LIGHT EMITTING DEVICE INCLUDING SAME

A novel compound for a light emitting device, and an organic light emitting device containing the same are disclosed. The compound for a light emitting device is represented by Formula 1 below:

##STR00001##

DIAZIRINES AS PHOTOCAGES WHICH RELEASE MOLECULES CONTAINING DOUBLE BONDS

The present invention relates to the field of fragrance storage means as used, for example, in the field of washing or cleaning compositions, cosmetic compositions and air freshening compositions. The invention relates to specific diazirines which function as thermally labile and acid-labile fragrance storage means. The present invention further relates to washing and cleaning compositions, cosmetic compositions and air freshening compositions comprising such diazirines. The invention further relates to a method of long-lasting fragrancing of surfaces, and likewise to a method of long-lasting room fragrancing.

DIAZIRINES AS PHOTOCAGES WHICH RELEASE MOLECULES CONTAINING DOUBLE BONDS

The present invention relates to the field of fragrance storage means as used, for example, in the field of washing or cleaning compositions, cosmetic compositions and air freshening compositions. The invention relates to specific diazirines which function as thermally labile and acid-labile fragrance storage means. The present invention further relates to washing and cleaning compositions, cosmetic compositions and air freshening compositions comprising such diazirines. The invention further relates to a method of long-lasting fragrancing of surfaces, and likewise to a method of long-lasting room fragrancing.

Compositions and methods for the treatment of cancer

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

Compositions and methods for the treatment of cancer

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

ANTI-FUNGALS COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SPHINGOLIPIDS

The present invention provides a compound having the structure:

##STR00001## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are each independently, H, halogen, CN, CF.sub.3, OCF.sub.3, NO.sub.2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, OH, OAc, OR.sub.13, COR.sub.13, CH.sub.2OR.sub.13, SH, SR.sub.13, SO.sub.2R.sub.13, NH.sub.2, NHR.sub.13, NR.sub.14R.sub.15, NHCOR.sub.12, or CONR.sub.14R.sub.15; R.sub.9, R.sub.10, R.sub.11, and R.sub.12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, OAc, COR.sub.13, SH, SR.sub.13, SO.sub.2R.sub.13, NH.sub.2, NHR.sub.13, NR.sub.14R.sub.15, NHCOR.sub.12, or CONR.sub.14R.sub.15; wherein each occurrence of R.sub.13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R.sub.14 is independently H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R.sub.15 is independently H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R.sub.14 is methyl, R.sub.15 is not methyl; wherein at least one of R.sub.9, R.sub.10, R.sub.11, and R.sub.12 is not H; wherein at least one of R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 is not H.

ANTI-FUNGALS COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SPHINGOLIPIDS

The present invention provides a compound having the structure:

##STR00001## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are each independently, H, halogen, CN, CF.sub.3, OCF.sub.3, NO.sub.2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, OH, OAc, OR.sub.13, COR.sub.13, CH.sub.2OR.sub.13, SH, SR.sub.13, SO.sub.2R.sub.13, NH.sub.2, NHR.sub.13, NR.sub.14R.sub.15, NHCOR.sub.12, or CONR.sub.14R.sub.15; R.sub.9, R.sub.10, R.sub.11, and R.sub.12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, OAc, COR.sub.13, SH, SR.sub.13, SO.sub.2R.sub.13, NH.sub.2, NHR.sub.13, NR.sub.14R.sub.15, NHCOR.sub.12, or CONR.sub.14R.sub.15; wherein each occurrence of R.sub.13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R.sub.14 is independently H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R.sub.15 is independently H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R.sub.14 is methyl, R.sub.15 is not methyl; wherein at least one of R.sub.9, R.sub.10, R.sub.11, and R.sub.12 is not H; wherein at least one of R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 is not H.