C07D265/28

ANTISENSE-INDUCED EXON EXCLUSION IN MYOSTATIN
20220090084 · 2022-03-24 ·

The present disclosure relates to antisense oligomers and related compositions and methods for decreasing the expression of functional human myostatin and methods for treating muscular dystrophy and related disorders and more specifically relates to inducing exclusion of myostatin exon 2 and thereby reducing levels of myostatin protein.

Aryl ethene derivative and pharmaceutical composition containing same as active ingredient

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.

Aryl ethene derivative and pharmaceutical composition containing same as active ingredient

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.

Antisense-induced exon exclusion in myostatin

The present disclosure relates to antisense oligomers and related compositions and methods for decreasing the expression of functional human myostatin and methods for treating muscular dystrophy and related disorders and more specifically relates to inducing exclusion of myostatin exon 2 and thereby reducing the levels of myostatin protein.

HETEROCYCLIC COMPOUNDS

The invention provides new heterocyclic compounds having the general formula (I)

##STR00001##

wherein A, B, L.sup.1, X, m, n, and RI to R.sup.7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

HETEROCYCLIC COMPOUNDS

The invention provides new heterocyclic compounds having the general formula (I)

##STR00001##

wherein A, B, L.sup.1, X, m, n, and RI to R.sup.7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Electrochromic compound, electrochromic composition, and electrochromic display element

Provided is an electrochromic compound represented by the following general formula (I) or (II) where R.sub.1 to R.sub.13 are each independently a hydrogen atom, a halogen atom, a monovalent organic group, or a polymerizable functional group, and at least one of the R.sub.1 to the R.sub.13 is a polymerizable functional group. ##STR00001##

Electrochromic compound, electrochromic composition, and electrochromic display element

Provided is an electrochromic compound represented by the following general formula (I) or (II) where R.sub.1 to R.sub.13 are each independently a hydrogen atom, a halogen atom, a monovalent organic group, or a polymerizable functional group, and at least one of the R.sub.1 to the R.sub.13 is a polymerizable functional group. ##STR00001##

Aryl ethene derivative and pharmaceutical composition containing same as active ingredient

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.

Aryl ethene derivative and pharmaceutical composition containing same as active ingredient

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.