C07D271/12

Compound and dimer complex embodiments for supramolecular sensing

Disclosed herein are embodiments of a compound that can be used as a supramolecular sensor for determining the presence of analytes (e.g., illicit drugs), and for identifying and/or quantifying the analytes. Also disclosed herein is a parallel synthesis method for making compound embodiments, as well as method embodiments for using the compound embodiments. Array embodiments comprising one or more compound embodiments disclosed herein also are described.

Compound and dimer complex embodiments for supramolecular sensing

Disclosed herein are embodiments of a compound that can be used as a supramolecular sensor for determining the presence of analytes (e.g., illicit drugs), and for identifying and/or quantifying the analytes. Also disclosed herein is a parallel synthesis method for making compound embodiments, as well as method embodiments for using the compound embodiments. Array embodiments comprising one or more compound embodiments disclosed herein also are described.

METHODS OF TREATING EPILEPSY USING THE SAME
20230114241 · 2023-04-13 ·

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same for the treatment of seizures, epilepsy related conditions, epilepsy-related syndrome, and the like as described herein.

NOVEL ACTIVATORS OF THE LIPIDATING TRANSPORTER ATP BINDING CASSETTE PROTEIN TYPE 1 (AB-CA1) AND THERAPEUTIC USES THEREOF
20230103965 · 2023-04-06 ·

The present invention relates to compounds that are functional activators of ATP binding cassette protein type 1 (AB-CA1), and their use for treating diseases and conditions implicating ABCA1, including Alzheimer's Disease (AD) and atherosclerosis.

NOVEL COMPOUND OR SALT THEREOF, COMPOSITION FOR CYSTEINE DETECTION, FLUORESCENT PROBE AND COMPOSITION FOR DIAGNOSING CANCER CONTAINING THE SAME, METHOD FOR DETECTING CYSTEINE, METHOD FOR PROVIDING INFORMATION FOR DIAGNOSING CANCER, AND METHOD FOR PRODUCING NOVEL COMPOUND

The present disclosure relates to a novel compound or a salt thereof, a composition for detecting cysteine, a fluorescent probe, and a composition for diagnosing cancer, which contain the same, a method for detecting cysteine, a method for providing information for diagnosing cancer, and a method for producing the novel compound. According to the present disclosure, there may be provided a method of synthesizing and purifying a fluorescent probe for cysteine detection and applying the same to diagnose cervical cancer by detecting cysteine in human urine.

NOVEL COMPOUND OR SALT THEREOF, COMPOSITION FOR CYSTEINE DETECTION, FLUORESCENT PROBE AND COMPOSITION FOR DIAGNOSING CANCER CONTAINING THE SAME, METHOD FOR DETECTING CYSTEINE, METHOD FOR PROVIDING INFORMATION FOR DIAGNOSING CANCER, AND METHOD FOR PRODUCING NOVEL COMPOUND

The present disclosure relates to a novel compound or a salt thereof, a composition for detecting cysteine, a fluorescent probe, and a composition for diagnosing cancer, which contain the same, a method for detecting cysteine, a method for providing information for diagnosing cancer, and a method for producing the novel compound. According to the present disclosure, there may be provided a method of synthesizing and purifying a fluorescent probe for cysteine detection and applying the same to diagnose cervical cancer by detecting cysteine in human urine.

MYC-MAX INHIBITOR COMPOUND THERAPEUTICS FOR CANCER TREATMENT, METHODS AND USES ASSOCIATED THEREWITH

Provided herein are Myc-Max inhibitory compounds having the structure of Formula (I) and compositions thereof for use in the treatment of cancer. In particular, the Myc-Max inhibitory compounds may be useful for the treatment of cancers selected from one or more of: prostate cancer, breast cancer, colon cancer, cervical cancer, small-cell lung carcinomas, neuroblastomas, osteosarcomas, glioblastomas, melanoma and myeloid leukaemia.

##STR00001##

Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors

This invention relates to compounds of Formula (I) wherein Cy.sup.1, L.sup.1, Y, R.sup.1, L.sup.2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions. ##STR00001##

Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors

This invention relates to compounds of Formula (I) wherein Cy.sup.1, L.sup.1, Y, R.sup.1, L.sup.2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions. ##STR00001##

COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE

The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.