The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

The present invention relates to a new type of low-dimensional hybrid post-perovskites for high efficiency white light emission. More precisely, the invention relates to a one dimensional post-perovskite of formula A.sub.aM.sub.mX.sub.x.yH.sub.2O wherein A is a cis- or trans-2,5-dialkylpiperazine derivative bearing C.sub.1-C.sub.3 linear or branched alkyl groups, M is one or more metal, X one or more halogen, 0<a<5, 1<m<2, 2<x<12, 0<y. The invention also relates to material and luminescent device comprising the same and methods of preparation of the of low-dimensional hybrid post-perovskites.

Described herein is the manufacture of MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate including salts thereof.

Described herein is the manufacture of MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate including salts thereof.

The present invention includes polycationic amphiphilic compounds of formula VII useful as antimicrobial agents. ##STR00001## The present invention further includes novel polymers of polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

The present invention relates to a new type of low-dimensional hybrid post-perovskites for high efficiency white light emission. More precisely, the invention relates to a one dimensional post-perovskite of formula A.sub.aM.sub.mX.sub.x.Math.yH.sub.2O wherein A is a cis- or trans-2,5-dialkylpiperazine derivative bearing C.sub.1-C.sub.3 linear or branched alkyl groups, M is one or more metal, X one or more halogen, 0<a<5, 1<m<2, 2<x<12, 0<y. The invention also relates to material and luminescent device comprising the same and methods of preparation of the of low-dimensional hybrid post-perovskites.

Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

##STR00001##

The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (1b), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients. ##STR00001##

The object of the present invention is to provide a new organic phosphorus ligand that can efficiently promote cross-coupling reaction to obtain the target substance at high yield, as well as a method of manufacturing such ligand whose steric characteristics and electronic characteristics can be fine-tuned and which can be used to cause cross-coupling reaction at high yield. As a means for achieving the aforementioned object, a phosphine compound expressed by General Formula (1) below is provided. ##STR00001##
(In the formula, R.sup.1 and R.sup.2 are each independently a secondary alkyl group, tertiary alkyl group, or cycloalkyl group, while R.sup.3 and R.sup.4 are each independently a hydrogen, aliphatic group, heteroaliphatic group, aromatic group, alicyclic group, or heterocyclic group. Note that R.sup.3 and R.sup.4 have no phosphorus atom and that R.sup.3 and R.sup.4 are not both hydrogen at the same time).

The object of the present invention is to provide a new organic phosphorus ligand that can efficiently promote cross-coupling reaction to obtain the target substance at high yield, as well as a method of manufacturing such ligand whose steric characteristics and electronic characteristics can be fine-tuned and which can be used to cause cross-coupling reaction at high yield. As a means for achieving the aforementioned object, a phosphine compound expressed by General Formula (1) below is provided. ##STR00001##
(In the formula, R.sup.1 and R.sup.2 are each independently a secondary alkyl group, tertiary alkyl group, or cycloalkyl group, while R.sup.3 and R.sup.4 are each independently a hydrogen, aliphatic group, heteroaliphatic group, aromatic group, alicyclic group, or heterocyclic group. Note that R.sup.3 and R.sup.4 have no phosphorus atom and that R.sup.3 and R.sup.4 are not both hydrogen at the same time).