The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

A polymerizable composition for an optical material of the present invention includes polyisocyanate (a) including aliphatic polyisocyanate (a1) and a modified aliphatic polyisocyanate (a2), an episulfide (b), and a polythiol (c).

A process for producing an episulfide compound for an optical material of the present invention includes a step of chlorinating glycerin to obtain dichloropropanol; a step of epoxidizing the dichloropropanol to obtain epichlorohydrin; a step of reacting the epichlorohydrin with a sulfating agent to obtain a bis(chlorohydrin) (di)sulfide compound thought a thiol compound; a step of epoxidizing the bis(chlorohydrin) (di)sulfide compound under basic conditions to obtain an epoxy compound; and a step of reacting the epoxy compound with a sulfating agent to obtain an episulfide compound represented by following General Formula (1):

##STR00001## wherein, in the formula, n represents 0 or 1.

A process for producing an episulfide compound for an optical material of the present invention includes a step of chlorinating glycerin to obtain dichloropropanol; a step of epoxidizing the dichloropropanol to obtain epichlorohydrin; a step of reacting the epichlorohydrin with a sulfating agent to obtain a bis(chlorohydrin) (di)sulfide compound thought a thiol compound; a step of epoxidizing the bis(chlorohydrin) (di)sulfide compound under basic conditions to obtain an epoxy compound; and a step of reacting the epoxy compound with a sulfating agent to obtain an episulfide compound represented by following General Formula (1):

##STR00001## wherein, in the formula, n represents 0 or 1.

A production method for an episulfide compound includes: (A) producing an episulfide compound having two or more units of the structure represented by the following formula (2) from an epoxy compound having two or more units of the structure represented by the following formula (1); and (B) adding a mixed solvent of a protic polar solvent and an aprotic polar solvent to the reaction solution obtained after (A) the producing of the episulfide compound.

##STR00001##

In formulae (1) and (2), R.sup.1 represents a hydrocarbon group containing 0 to 10 carbon atoms, R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrocarbon group containing 1 to 10 carbon atoms or a hydrogen atom, Y represents O, S, Se or Te, and n represents 0 or 1.

A production method for an episulfide compound includes: (A) producing an episulfide compound having two or more units of the structure represented by the following formula (2) from an epoxy compound having two or more units of the structure represented by the following formula (1); and (B) adding a mixed solvent of a protic polar solvent and an aprotic polar solvent to the reaction solution obtained after (A) the producing of the episulfide compound.

##STR00001##

In formulae (1) and (2), R.sup.1 represents a hydrocarbon group containing 0 to 10 carbon atoms, R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrocarbon group containing 1 to 10 carbon atoms or a hydrogen atom, Y represents O, S, Se or Te, and n represents 0 or 1.

A battery includes a cathode including a cathode active material, an anode comprising lithium, and an electrolyte including an aprotic solvent, a lithium salt, and a compound or mixture of two or more different compounds each containing at least one epi-sulfide group.

A battery includes a cathode including a cathode active material, an anode comprising lithium, and an electrolyte including an aprotic solvent, a lithium salt, and a compound or mixture of two or more different compounds each containing at least one epi-sulfide group.

The fluorene compound is represented by formula (1), which contains thioepoxy and (meth)allyl groups. In the formula, R.sup.1 to R.sup.4 are each independently a hydrogen atom or a methyl group. The fluorene compound containing thioepoxy and (meth)allyl groups allows for both polymerization via (meth)allyl groups and polymerization via thioepoxy groups.

##STR00001##

The fluorene compound is represented by formula (1), which contains thioepoxy and (meth)allyl groups. In the formula, R.sup.1 to R.sup.4 are each independently a hydrogen atom or a methyl group. The fluorene compound containing thioepoxy and (meth)allyl groups allows for both polymerization via (meth)allyl groups and polymerization via thioepoxy groups.

##STR00001##