Patent classifications
C07D471/22
SMARCA INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
Compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
Compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
Polycyclic carbamoylpyridone derivative
The present invention provides a compound represented by Formula (I): ##STR00001##
wherein ring A is a substituted or unsubstituted heterocycle; ring C is a benzene ring or the like; R.sup.1 is halogen or the like; R.sup.2a and R.sup.2b are each independently hydrogen or the like; R.sup.3 is substituted or unsubstituted alkyl or the like; R.sup.4 is hydrogen or the like; and n is an integer of 1 to 3.
Polycyclic carbamoylpyridone derivative
The present invention provides a compound represented by Formula (I): ##STR00001##
wherein ring A is a substituted or unsubstituted heterocycle; ring C is a benzene ring or the like; R.sup.1 is halogen or the like; R.sup.2a and R.sup.2b are each independently hydrogen or the like; R.sup.3 is substituted or unsubstituted alkyl or the like; R.sup.4 is hydrogen or the like; and n is an integer of 1 to 3.
MECHANICAL-BOND-PROTECTED STABLE BISRADICALS
Disclosed herein are compositions comprising air-stable radical [2]catenanes and method of making the same. The [2]catenane comprises a first macrocyclic ring mechanically interlocked with a second macrocyclic ring where each of the first macrocyclic ring and the second macrocyclic ring comprise an alternating cyclic arrangement of a first unsubstituted or substituted 4,4′-bipyridinium (BIPY) subunit, a first unsubstituted or substituted phenylene subunit, a second unsubstituted or substituted BIPY subunit, and a second unsubstituted or substituted phenylene subunit forming a macrocycle.
TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents A, R.sup.1, R.sup.2, R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and n are as defined herein. The inventions also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds and methods of preparing the compounds.
##STR00001##
TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents A, R.sup.1, R.sup.2, R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and n are as defined herein. The inventions also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds and methods of preparing the compounds.
##STR00001##
PIKFYVE KINASE INHIBITORS
The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.
MACROCYCLIC PAD4 INHIBITORS USEFUL AS IMMUNOSUPPRESSANT
The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A.sub.1, A.sub.2, A.sub.3, A.sub.4, Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 along with other variables are as defined herein.
##STR00001##