The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A.sub.1, A.sub.2, A.sub.3, A.sub.4, Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 along with other variables are as defined herein.

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The present invention relates to a novel compound (formula I), which has cancer treatment activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition containing the compound.

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The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R.sup.1-R.sup.4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X.sub.3 or P2X.sub.2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. ##STR00001##

The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R.sup.1-R.sup.4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X.sub.3 or P2X.sub.2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. ##STR00001##

A wellbore fluid may include a base fluid and at least one cationic heterocyclic polymer in an amount effective to increase a viscosity of the base fluid, the cationic heterocyclic polymer includes at least two distinct cyclic monomers, at least one of which has at least two heteroatoms in the cyclic structure. A method of drilling a wellbore may introduce such wellbore fluid into the wellbore. A method of producing a cationic heterocyclic polymer may include reacting, in a solvent selected from the group that includes tetrahydrofuran, dioxane, dichloromethane, alcoholic solvents, chlorinated solvents, aromatic hydrocarbon solvents, or mixture thereof, at least two distinct cyclic monomers, at least one of which has at least two heteroatoms in the cyclic structure.

A wellbore fluid may include a base fluid and at least one cationic heterocyclic polymer in an amount effective to increase a viscosity of the base fluid, the cationic heterocyclic polymer includes at least two distinct cyclic monomers, at least one of which has at least two heteroatoms in the cyclic structure. A method of drilling a wellbore may introduce such wellbore fluid into the wellbore. A method of producing a cationic heterocyclic polymer may include reacting, in a solvent selected from the group that includes tetrahydrofuran, dioxane, dichloromethane, alcoholic solvents, chlorinated solvents, aromatic hydrocarbon solvents, or mixture thereof, at least two distinct cyclic monomers, at least one of which has at least two heteroatoms in the cyclic structure.

Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications are provided.

Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications are provided.

Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

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Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

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