Patent classifications
C07D473/40
NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM
Oligomers can be prepared from bicyclic nucleoside. The nucleosides can be a compound of formula (I)
##STR00001##
in which each of T.sub.1 and T.sub.2 is independently OR.sub.1 or OR.sub.2; R.sub.1 is H or a hydroxyl protecting group, R.sub.2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
SUBSTITUTED QUINOXALINE DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
SUBSTITUTED QUINOXALINE DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Carbocyclic nucleoside reverse transcriptase inhibitors
The present invention is directed carbocyclic nucleoside reverse transcriptase inhibitors compounds of Formula I ##STR00001##
and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
Carbocyclic nucleoside reverse transcriptase inhibitors
The present invention is directed carbocyclic nucleoside reverse transcriptase inhibitors compounds of Formula I ##STR00001##
and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
Reagent and kit for enhancing chemiluminescent reaction
A reagent for enhancing a chemiluminescent reaction includes luminol or luminol derivatives, an oxidant, an electron mediator, and an enhancer. The enhancer is a nitrogen-containing fused heterocyclic compound having at least two nitrogen atoms. The present disclosure further provides a kit for enhancing a chemiluminescent reaction comprising the foregoing reagent.
Reagent and kit for enhancing chemiluminescent reaction
A reagent for enhancing a chemiluminescent reaction includes luminol or luminol derivatives, an oxidant, an electron mediator, and an enhancer. The enhancer is a nitrogen-containing fused heterocyclic compound having at least two nitrogen atoms. The present disclosure further provides a kit for enhancing a chemiluminescent reaction comprising the foregoing reagent.
Intermediates useful in the synthesis of compounds as modulators of protein kinases
The present invention provides compounds of formula (10), formula (12), formula (14) and formula (15) ##STR00001## wherein R, R.sup.1, R.sup.2, Cy.sup.1 and X are as described herein.
Intermediates useful in the synthesis of compounds as modulators of protein kinases
The present invention provides compounds of formula (10), formula (12), formula (14) and formula (15) ##STR00001## wherein R, R.sup.1, R.sup.2, Cy.sup.1 and X are as described herein.
METHOD FOR SYNTHESIZING DIVERSELY SUBSTITUTED PURINES
The present invention relates to a method for synthesizing diversely substituted purines starting from a pyrimidine. Formula (I). The method comprises the formation of an amidine group on the pyrimidine by implementing a Vilsmeier type reagent, the functionalization of the pyrimidine with an amine and the cyclization to form the purine nucleus. Optional steps can also be performed in order to further functionalize the molecule. The invention also relates to new purines and new intermediate product.
##STR00001##