Disclosed are compounds which can act as a positive allosteric modulator for erythropoietin and erythropoietin receptor and have the activity in promoting erythropoiesis. Also disclosed are pharmaceutical compositions comprising said compounds and treatment methods utilizing said compounds.

The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed.

Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed.

Conjugates of 2,3-dihydroxynaphthalene and its derivatives with enzyme cleavable groups are chromogenic substrates that form colored compounds when complexed with metal ions, e.g. iron ions, on cleavage by enzymes, and are useful in microbial detection and identification. The cleavage products form purple or red-brown colored complexes, that can easily be observed by the naked eye. Microbes can be grown in the presence of the substrates and the metal salts that provide the metal ion for complexing with the 2,3-dihydroxynaphthalene product. Substituents in the naphthalene ring may affect the solubility of the substrates and also the diffusibility and color of the metal complexes. Some of the substrates yield soluble complexes on cleavage and are of particular value in liquid growth media. Other substrates produce less soluble complexes that are more suitable for use in solid agar media. Methods of synthesizing the substrates are described.

Conjugates of 2,3-dihydroxynaphthalene and its derivatives with enzyme cleavable groups are chromogenic substrates that form colored compounds when complexed with metal ions, e.g. iron ions, on cleavage by enzymes, and are useful in microbial detection and identification. The cleavage products form purple or red-brown colored complexes, that can easily be observed by the naked eye. Microbes can be grown in the presence of the substrates and the metal salts that provide the metal ion for complexing with the 2,3-dihydroxynaphthalene product. Substituents in the naphthalene ring may affect the solubility of the substrates and also the diffusibility and color of the metal complexes. Some of the substrates yield soluble complexes on cleavage and are of particular value in liquid growth media. Other substrates produce less soluble complexes that are more suitable for use in solid agar media. Methods of synthesizing the substrates are described.

A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells. Preferably the triclosan derivative is a glycoside derivative, more preferably a pyranoside derivative. Suitably a selective medium comprising said selective agent and methods of culturing cells using the selective agent are provided.

A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells. Preferably the triclosan derivative is a glycoside derivative, more preferably a pyranoside derivative. Suitably a selective medium comprising said selective agent and methods of culturing cells using the selective agent are provided.

The porous polymer compound has a three dimensional skeleton and pores and/or voids that are partitioned and formed by the three dimensional skeleton. The three dimensional skeleton comprises multiple sugar derivatives represented by formula (1) and multiple cations that interact with the hydroxyl groups and/or ether bonds of the sugar derivatives, and the three-dimensional skeleton is formed by each of the cations interacting with two or more sugar derivatives. Also provided are a method of separating a compound to be separated using the porous polymer compound; a single crystal of the porous polymer compound; a method of preparing a sample for crystal structure analysis using the single crystal; a method of determining a molecular structure of a compound to be analyzed using the sample for crystal structure analysis; and a method of determining an absolute configuration of a chiral compound using the sample for crystal structure analysis.