The photolabile hydrazine linker of the present invention is based on the o-nitro-veratryl group, which is capable of releasing hydrazide derivatives upon UV irradiation. The linker allows for a new solid-phase peptide synthesis (SPPS) strategy which is fully orthogonal to the most commonly used protecting groups and chemical methods in SPPS and shows excellent compatibility with peptide composition, notably the 20 naturally occurring α-amino acid residues (even in their side-chain protected form) are accepted in the C-terminal of the peptide hydrazides. Furthermore, the linker unit can be applied to synthesize combinatorial libraries of biological interesting heterocyclic compounds, such as pyranopyrazoles.

A keratin hydrolysate including at least 88% by weight of free amino acids relative to the total weight of the amino acids of the hydrolysate and including a content of free tyrosine between 2% and 4% by weight relative to the total weight of the free amino acids of the hydrolysate. Also, a method for preparing the hydrolysate including the following steps: acid hydrolysis, a pH adjustment and a desalination. Also, the use of the hydrolysate for pet food, aquaculture food, and plant biostimulants.

A keratin hydrolysate including at least 88% by weight of free amino acids relative to the total weight of the amino acids of the hydrolysate and including a content of free tyrosine between 2% and 4% by weight relative to the total weight of the free amino acids of the hydrolysate. Also, a method for preparing the hydrolysate including the following steps: acid hydrolysis, a pH adjustment and a desalination. Also, the use of the hydrolysate for pet food, aquaculture food, and plant biostimulants.

The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.

The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.

The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.

The present invention relates to aqueous peptide-stabilized polyurethane dispersions that can be used in various applications including adhesives and cosmetics, as they are surfactant and solvent free and have low VOC emissions. As hybrid materials, they provide for a versatile system that can be finely tuned and combine the advantageous properties of polyurethane and peptide materials. Also encompassed are processes for their production including dispersing an NCO-terminated polyurethane prepolymer into a continuous aqueous phase comprising one or more peptides, thereby forming peptide-stabilized polyurethane particles, compositions containing them and their use in cosmetics and adhesives.

The present invention relates to aqueous peptide-stabilized polyurethane dispersions that can be used in various applications including adhesives and cosmetics, as they are surfactant and solvent free and have low VOC emissions. As hybrid materials, they provide for a versatile system that can be finely tuned and combine the advantageous properties of polyurethane and peptide materials. Also encompassed are processes for their production including dispersing an NCO-terminated polyurethane prepolymer into a continuous aqueous phase comprising one or more peptides, thereby forming peptide-stabilized polyurethane particles, compositions containing them and their use in cosmetics and adhesives.

A hybrid vegetable protein is described, comprising a guest protein having the structure of prolamine and glutelin, and a host protein having the structure of globulin and albumin, obtained from vegetable grains, such as corn and soybean, respectively. Likewise, a method for obtaining said hybrid vegetable protein is described, which comprises the steps of extracting the guest and host proteins, carrying out an acidification thereof, and further applying a magnetic field to provoke their attachment, and finally adding an alkali to the attached proteins to obtain a hybrid vegetable protein at its isoelectric point. The protein thus produced has a value higher than 0.97 according to the PDCAAS rating.

A hybrid vegetable protein is described, comprising a guest protein having the structure of prolamine and glutelin, and a host protein having the structure of globulin and albumin, obtained from vegetable grains, such as corn and soybean, respectively. Likewise, a method for obtaining said hybrid vegetable protein is described, which comprises the steps of extracting the guest and host proteins, carrying out an acidification thereof, and further applying a magnetic field to provoke their attachment, and finally adding an alkali to the attached proteins to obtain a hybrid vegetable protein at its isoelectric point. The protein thus produced has a value higher than 0.97 according to the PDCAAS rating.