The present disclosure relates to a method/system for preparing encapsulated exosomes from a biological sample containing exosomes, said method comprising: a) dispersing inorganic oxide particles into a buffer solution comprising a polymer and a biological sample comprising exosomes, b) allowing the polymer to react with the inorganic oxide particles to form capsules, wherein the exosomes are inside the capsules. The present disclosure also relates to a method/system for isolating and purifying encapsulated exosomes, said method comprising: a) preparing an aqueous micellar system comprising at least one surfactant, and at least one salt; b) mixing a biological sample containing encapsulated exosomes with the aqueous micellar system from step a); c) allowing the aqueous micellar system to phase separate, wherein the surfactant partitions substantially into one phase, and the other phase has a lower concentration of surfactant; and d) obtaining the encapsulated exosomes from the capsule-rich phase.

Suggested is a plant peptide fraction, obtainable or obtained according to the following steps: (a) providing oat seeds; (b) dehulling and milling said oat seeds; (c) subjecting the seeds of step (b) to an extraction to obtain a first peptide fraction; (d) subjecting the first peptide fraction of step (c) to enzymatic hydrolysis; (e) subjecting the hydrolyzed peptide fraction of step (d) to ultra- and/or nanofiltration to obtain a retentate and a permeate, said permeate enriched in peptide s showing a molecular weight below 2,000 Dalton; and (f) optionally drying the permeate of step (e).

Suggested is a plant peptide fraction, obtainable or obtained according to the following steps: (a) providing oat seeds; (b) dehulling and milling said oat seeds; (c) subjecting the seeds of step (b) to an extraction to obtain a first peptide fraction; (d) subjecting the first peptide fraction of step (c) to enzymatic hydrolysis; (e) subjecting the hydrolyzed peptide fraction of step (d) to ultra- and/or nanofiltration to obtain a retentate and a permeate, said permeate enriched in peptide s showing a molecular weight below 2,000 Dalton; and (f) optionally drying the permeate of step (e).

A process for the extraction of collagen from collagen-containing matter, wherein the process comprises; incubating the collagen-containing matter in an acidic solution to form an incubant, then diafiltrating the incubant to substantially purify solubilised collagen within the incubant, thereby forming a retentate, then separating the soluble and insoluble matter of the retentate to remove the remaining insoluble matter, wherein the soluble matter is a substantially pure collagen solution.

The disclosure relates to methods to control trace metals during production of anti-CD38 antibodies, drug substances and drug products generated using the methods, and uses of the generated drug substances and drug products.

The disclosure relates to methods to control trace metals during production of anti-CD38 antibodies, drug substances and drug products generated using the methods, and uses of the generated drug substances and drug products.

The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures.

An object of the present invention is to provide, as a method for producing an antibody at a lower cost than the prior art, a method for purifying an antibody in a non-adsorption mode using an inorganic compound containing silicon dioxide and aluminum oxide, a method for producing an antibody comprising the purification method, and an antibody produced by the production method, and the like. The present invention relates to a method for purifying an antibody in a non-adsorption mode using an inorganic compound containing silicon dioxide and aluminum oxide, a method for producing an antibody comprising the purification method, and an antibody produced by the production method.

An object of the present invention is to provide, as a method for producing an antibody at a lower cost than the prior art, a method for purifying an antibody in a non-adsorption mode using an inorganic compound containing silicon dioxide and aluminum oxide, a method for producing an antibody comprising the purification method, and an antibody produced by the production method, and the like. The present invention relates to a method for purifying an antibody in a non-adsorption mode using an inorganic compound containing silicon dioxide and aluminum oxide, a method for producing an antibody comprising the purification method, and an antibody produced by the production method.

The invention aims to provide an immunoglobulin-binding protein having improved chemical stability, especially stability against alkali. The object can be achieved by improving stability against alkali by substituting an amino acid residue(s) at a particular position(s) in an immunoglobulin-binding domain such as domain C of protein A derived from a bacterium belonging to the genus Staphylococcus, to another/other particular amino acid residue(s).