C07K4/10

ALLERGY ANTIGEN AND EPITOPE THEREOF
20210292383 · 2021-09-23 ·

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an allergen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and food raw materials or edible processed products in which an antigen comprising such a polypeptide is eliminated or reduced, or the polypeptide is cleaved or removed. The present invention further relates to a tester for determining the presence or absence of an antigen in an object of interest.

COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES

A compound of formula (I) R.sub.1-W.sub.m-X.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-AA.sub.7-AA.sub.8-AA.sub.9-Y.sub.p-Z.sub.q-R.sub.2, wherein AA.sub.1 is Phe; AA.sub.2 is Trp; AA.sub.3 is selected from Met, Leu and Ile; AA.sub.4 is selected from Lys, Arg and Gln; AA.sub.5 is Arg; AA.sub.6 is Lys; AA.sub.7 is selected from Arg, Lys and His; AA.sub.8 is selected from Val, Ile, Leu and Met; and AA.sub.9 is Pro. The compound is useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energizing the skin and as an anti-aging agent.

COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES

A compound of formula (I) R.sub.1-W.sub.m-X.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-AA.sub.7-AA.sub.8-AA.sub.9-Y.sub.p-Z.sub.q-R.sub.2, wherein AA.sub.1 is Phe; AA.sub.2 is Trp; AA.sub.3 is selected from Met, Leu and Ile; AA.sub.4 is selected from Lys, Arg and Gln; AA.sub.5 is Arg; AA.sub.6 is Lys; AA.sub.7 is selected from Arg, Lys and His; AA.sub.8 is selected from Val, Ile, Leu and Met; and AA.sub.9 is Pro. The compound is useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energizing the skin and as an anti-aging agent.

Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes

A compound of formula (1) R.sub.1W.sub.mX.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-AA.sub.7-AA.sub.8-AA.sub.9-Y.sub.pZ.sub.qR.sub.2, wherein AA.sub.1 is Phe; AA.sub.2 is Trp; AA.sub.3 is selected from Met, Leu and lie; AA.sub.4 is selected from Lys, Arg and Gln; AA.sub.5 is Arg; AA.sub.6 is Lys; AA.sub.7 is selected from Arg, Lys and His; AA.sub.8 is selected from Val, Ile, Leu and Met; and AA.sub.9 is Pro. The compound is useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energizing the skin and as an anti-aging agent.

Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes

A compound of formula (1) R.sub.1W.sub.mX.sub.n-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA.sub.6-AA.sub.7-AA.sub.8-AA.sub.9-Y.sub.pZ.sub.qR.sub.2, wherein AA.sub.1 is Phe; AA.sub.2 is Trp; AA.sub.3 is selected from Met, Leu and lie; AA.sub.4 is selected from Lys, Arg and Gln; AA.sub.5 is Arg; AA.sub.6 is Lys; AA.sub.7 is selected from Arg, Lys and His; AA.sub.8 is selected from Val, Ile, Leu and Met; and AA.sub.9 is Pro. The compound is useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energizing the skin and as an anti-aging agent.

SOYBEAN ALLERGY ANTIGEN

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest.

SOYBEAN ALLERGY ANTIGEN

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest.

SOYBEAN ALLERGY ANTIGEN

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest.

SOYBEAN ALLERGY ANTIGEN

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest.

Method for extracting proteins and functional lipid from soybean liquid by directional continuous catalysis with nano magnetic immobilized enzymes

The present invention relates to fields of continuous directional catalysis of soybean slurry to extract protein and functional oil with nano-magnetic immobilized enzymes. The present invention discloses soybean slurry as raw material and continuous mobile phase, and nano-magnetic immobilized enzymes as stationary phase applied in three-phase magnetic fluidized bed. The present invention provides a method of enzymatic disrupting cell walls by nano-magnetic immobilized enzyme cocktail including cellulose, pectinase and alkaline protease. The method can he used to break down lipoprotein, lipopolysaccharide complex and break lipoprotein film on the surface of lipoprotein to release the lipid. The present invention also provides a method to catalyze phospholipid using nano-magnetic immobilized phospholipase to change the polarity of phospholipids and control liquid emulsification phenomenon. The enzymes disclosed in the present invention do not interfere with each other. The preparation method can be used to catalyze soybean slurry continuously using the nano-magnetic immobilized enzymes to extract protein and functional lipid simultaneously.